| Gene Symbol | TIMM10 |
| Full Name | Mitochondrial Import Inner Membrane Translocase Subunit Tim10 |
| Function | TIMM10 (Translocase of Inner Mitochondrial Membrane 10) is a small essential subunit of the TIM22 complex, which mediates the insertion of carrier proteins into the inner mitochondrial membrane. |
| Primary Expression | neurons throughout the CNS - Regional Distribution: High expression in basal ganglia, hippocampus, and motor [cortex |
| Pathways | Unfolded Protein Response, Mitophagy, Mtor |
| GeneCards | TIMM10 |
| Human Protein Atlas | TIMM10 |
| Cellular respiration | Proper assembly of the electron transport chain |
| Metabolic regulation | Transport of substrates and products |
| Calcium homeostasis | Mitochondrial calcium uptake |
| [Apoptosis](/entities/apoptosis) | Release of cytochrome c and other pro-apoptotic factors [2] |
| Brain | Widely expressed in neurons throughout the CNS |
| Regional Distribution | High expression in basal ganglia, hippocampus, and motor cortex |
| Upregulation | Induced during mitochondrial biogenesis and in response to mitochondrial stress |
| Cellular Localization | Mitochondrial intermembrane space |
| Associated Diseases | neurodegeneration |
| Interactions | BECN1, BNIP3, BNIP3L, CEBPB, DDIT3, DNM1L |
| KG Connections | 43 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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