| Gene Symbol | TIMM10 |
| Full Name | Mitochondrial Import Inner Membrane Translocase Subunit Tim10 |
| Aliases | TIMM10PROTEIN |
| Function | TIMM10 (Translocase of Inner Mitochondrial Membrane 10) is a small essential subunit of the TIM22 complex, which mediates the insertion of carrier proteins into the inner mitochondrial membrane. |
| Primary Expression | neurons throughout the CNS - Regional Distribution: High expression in basal ganglia, hippocampus, and motor [cortex |
| Pathways | Unfolded Protein Response, Mitophagy, Mtor |
| GeneCards | TIMM10 |
| Human Protein Atlas | TIMM10 |
| Zinc-finger domain | Two zinc-binding motifs (CX2C, CX3H) that coordinate Zn2+ ions |
| α-helical structure | Forms a rod-like scaffold for protein interactions |
| Dimer formation | Functions as a homodimer or heterodimer with TIMM10B |
| Tim9-Tim10 complex | Forms a hexameric chaperone complex (Tim9-Tim10)2-Tim10 [1] |
| Metabolite carriers | UCP, PiC, CitC, AAC |
| Ion channels | MCU, LetM1 |
| Other IMS proteins | Small IMS proteins |
| Associated Diseases | neurodegeneration |
| Interactions | BECN1, BNIP3, BNIP3L, CEBPB, DDIT3, DNM1L |
| KG Connections | 43 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!