concept

SYNAPTIC FUNCTION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNAPTIC FUNCTION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

37Connections

1Hypotheses

0Analyses

3Outgoing

34Incoming

0Experiments

0Debates

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💡 Concept Info

Name	SYNAPTIC FUNCTION

Pathway Diagram

graph TD
    SYNAPTIC_FUNCTION["SYNAPTIC FUNCTION"]
    SYNAPTIC_FUNCTION -->|"involved_in"| Alzheimer_s_Disease["Alzheimer's Disease"]
    LIMK1_Cofilin_Axis["LIMK1-Cofilin Axis"] -->|"regulates"| SYNAPTIC_FUNCTION
    NEUROTROPHINS["NEUROTROPHINS"] -->|"modulates"| SYNAPTIC_FUNCTION
    TNFR2["TNFR2"] -->|"regulates"| SYNAPTIC_FUNCTION
    TNFR1["TNFR1"] -->|"regulates"| SYNAPTIC_FUNCTION
    mAb2A7["mAb2A7"] -->|"modulates"| SYNAPTIC_FUNCTION
    NPTX1["NPTX1"] -.biomarker for.-> SYNAPTIC_FUNCTION
    TYROBP["TYROBP"] -->|"regulates"| SYNAPTIC_FUNCTION
    GSK3__["GSK3-beta"] -->|"regulates"| SYNAPTIC_FUNCTION

Outgoing (3)

Target	Relation	Type	Str
cognitive resilience	mediates	phenotype	0.85
Cognitive Resilience	contributes_to	phenotype	0.85
Alzheimer's Disease	involved_in	disease	0.80

Incoming (34)

Source	Relation	Type	Str
RLN	regulates	protein	0.95
LIMK1-Cofilin Axis	regulates	pathway	0.90
APOE	involved_in	protein	0.90
NEUROTROPHINS	modulates	protein	0.90
BIN1	regulates	protein	0.85
mAb2A7	modulates	drug	0.85
PPARGC1A	regulates	gene	0.85
N-acetyl-l-leucine	associated_with	compound	0.85
NPTX1	biomarker_for	protein	0.85
RELN	regulates	gene	0.85
CYTOKINES	regulates	protein	0.80
TNF	regulates	entity	0.80
Rg1	regulates	compound	0.80
SNAP25	involved_in	gene	0.80
APOE	associated_with	gene	0.80
ASTROCYTES	regulates	cell_type	0.80
mTOR Signaling	modulates	pathway	0.80
PSD95	involved_in	protein	0.80
GLP-1	protects_against	protein	0.80
APOE	modulates	protein	0.80
SYNAPSIN-1	involved_in	protein	0.80
GSK3-β	regulates	enzyme	0.80
TYROBP	regulates	protein	0.80
Mab2A7	associated_with	drug	0.80
Complement Pathway	modulates	pathway	0.75
ER Stress	associated_with	process	0.75
TYROBP	involved_in	protein	0.75
Unfolded Protein Response	associated_with	pathway	0.75
APOE	affects	gene	0.70
BDNF/TrkB	regulates	pathway	0.70
alpha-synuclein	modulates	gene	0.70
PTK2B	involved_in	gene	0.60
24387789	is associated with	paper	0.60
LRRK2	disrupts	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CSF p-tau217 Normalization Requires Intact Synaptic Function	0.515	neurodegeneration	-

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SYNAPTIC FUNCTION in their description or question text

No additional research found