Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Synaptic Vesicle Tau Capture Inhibition: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's Disease | therapeutic_target | disease | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SNAP25 | regulates | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Synaptic Vesicle Tau Capture Inhibition | 0.554 | Alzheimer's Disease | Tau propagation mechanisms and therapeut |
| Synaptic Vesicle Tau Capture Inhibition | 0.547 | neurodegeneration | Tau propagation mechanisms and therapeut |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 15 hypotheses Top: 0.814
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Bioinformatics analysis and hub gene identification | exploratory | Alzheimer's disease | 0.800 | 0.00 | computational analysis of tran | proposed | N/A |
| s:** - Compare tau strain spreading in EXT1/EXT2 conditional knockout | falsification | Neurodegeneration | 0.400 | 0.50 | mouse | proposed | $260,000 |
| 4R-Tau Targeting Therapies for PSP and CBS | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Anti-Tau Immunotherapy Dosing Optimization | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy in 4R-Tau | validation | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $170,000 |
| Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Trials Have N | clinical | ALS | 0.400 | 0.50 | human | proposed | $7,500,000 |
| CBS vs PSP Phenotype Determinants — Single-Nucleus Multi-Omics Study | validation | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $160,000 |
| Pre-Symptomatic Tau Detection in MAPT Mutation Carriers | clinical | ALS | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Prion Strain Diversity and Selective Vulnerability | clinical | Alzheimer's Disease | 0.400 | 0.50 | mouse | proposed | $400,000 |
| Synaptic Vesicle Trafficking Dysfunction Validation in Parkinson's Dis | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Machine Learning and Novel Biomarkers for the Diagnosis of Alzheimer's Disease. [PMID:33803217] | Chang CH, Lin CH, Lane HY | Int J Mol Sci | 2021 | 1 |
| Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal stor [PMID:33111641] | Zhang X, Wei M, Fan J, Yan W, Zha X, Son | Autophagy | 2021 | 1 |
| Biomarkers of synaptic degeneration in Alzheimer's disease. [PMID:39701184] | Cheng Q, Fan Y, Zhang P, Liu H, Han J, Y | Ageing research reviews | 2025 | 0 |
| Common Mechanism Underlying Synaptic Dysfunction Caused by Preformed Fibril-Indu [PMID:41027737] | ["Dimitrov D", "Raja S", "Noor H", "Taka | The Journal of neuroscience : | 2025 | 0 |
| Reduced synaptic vesicle protein 2A in extracellular vesicles and brains of Alzh [PMID:40993829] | Nussbaumer J, Barve A, Zufferey V, Espou | Translational neurodegeneratio | 2025 | 0 |
| SNAP25 variant I67N: synaptic phenotypes, drug response and proteome changes in [PMID:40181518] | Østergaard M, Barbagallo P, Frederiksen | Brain : a journal of neurology | 2025 | 0 |
| Microglia mediate memory dysfunction via excitatory synaptic elimination in a fr [PMID:39285282] | ["Li S", "Liu H", "Lv P", "Yao Y", "Peng | Journal of neuroinflammation | 2024 | 0 |
| CB1R dysfunction of inhibitory synapses in the ACC drives chronic social isolati [PMID:37992714] | ["Guo B", "Xi K", "Mao H", "Ren K", "Xia | Neuron | 2024 | 0 |
| Assessment of the Spatial Distribution of Moisture Content in Granular Material [PMID:31234567] | ["Porzuczek J"] | Sensors (Basel, Switzerland) | 2024 | 0 |
| Cerebrospinal fluid biomarker panel for synaptic dysfunction in a broad spectrum [PMID:38325331] | Nilsson J, Pichet Binette A, Palmqvist S | Brain | 2024 | 0 |
| The Relationship between SNAP25 and Some Common Human Neurological Syndromes. [PMID:38963116] | Shu J, Peng F, Li J, Liu Y, Li X et al. | Curr Pharm Des | 2024 | 0 |
| Identification of early Alzheimer's disease subclass and signature genes based o [PMID:39650656] | Wang W, Lu J, Pan N, Zhang H, Dai J et a | Front Immunol | 2024 | 0 |
| Identification of early Alzheimer's disease subclass and signature genes based o [PMID:39650656] | Wang W, Lu J, Pan N, Zhang H, Dai J, Li | Frontiers in immunology | 2024 | 0 |
| A vision-based real-time traffic flow monitoring system for road intersections. [PMID:36789012] | ["Azimjonov J", "\u00d6zmen A", "Varan M | Multimedia tools and applicati | 2023 | 0 |
| Munc13- and SNAP25-dependent molecular bridges play a key role in synaptic vesic [PMID:37343100] | Papantoniou C, Laugks U, Betzin J, Capit | Science advances | 2023 | 0 |
| Copper Induces Cognitive Impairment in Mice via Modulation of Cuproptosis and CR [PMID:36839332] | Zhang Y, Zhou Q, Lu L, Su Y, Shi W, Zhan | Nutrients | 2023 | 0 |
| Concerns about the reliability of a trial of oral progesterone for preterm birth [PMID:35654321] | Gravesteijn Benjamin Y; Thornton Jim G; | American Journal of Obstetrics | 2022 | 0 |
| Disorders of synaptic vesicle fusion machinery. [PMID:32916768] | Melland H, Arvell EH, Gordon SL | J Neurochem | 2021 | 0 |
| Cysteine string proteins. [PMID:32044380] | Gundersen CB | Prog Neurobiol | 2020 | 0 |
| Sex Differences in Frail Older Adults with Foot Pain in a Spanish Population: An [PMID:32847063] | ["Navarro-Flores E", "Romero-Morales C", | International journal of envir | 2020 | 0 |
Multi-agent debates referencing this entity