Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about COGNITIVE_DECLINE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| SLC17A7 | loss_correlates_with | gene | 0.85 |
| SYNAPSE | causes | gene | 0.80 |
| Fahr_disease | causes | disease | 0.72 |
| TET2_deficiency | causes | mechanism | 0.70 |
| soluble_tau_oligomers | associated_with | protein | 0.70 |
| neuroinflammation | causes | mechanism | 0.70 |
| PD_ProS | associated_with | phenotype | 0.64 |
| circadian_disruption | causes | phenotype | 0.60 |
| TNFRSF25 | promotes | gene | 0.50 |
| melatonin | prevents | drug | 0.50 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-04 | 14 hypotheses Top: 0.651
neurodegeneration | 2026-04-03 | 43 hypotheses Top: 0.893
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.756
neurodegeneration | 2026-04-01 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Young adult microglial deletion of C1q reduces engulfment of synapses and preven [PMID:41000995] | Petrisko TJ, Chu SH, Gomez-Arboledas A, | bioRxiv : the preprint server | 2025 | 1 |
| The Role of Complement in Synaptic Pruning and Neurodegeneration. [PMID:34595138] | Gomez-Arboledas A, Acharya MM, Tenner AJ | ImmunoTargets and therapy | 2021 | 1 |
| Pioglitazone attenuates complement-mediated microglial synaptic engulfment in an [PMID:41396874] | Unknown | Brain : a journal of neurology | 2026 | 0 |
| C5aR1 signaling promotes region- and age-dependent synaptic pruning in models of [PMID:38278523] | ["Angela Gomez-Arboledas", "Maria I Fons | Alzheimer's & dementia : t | 2024 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 1.00 · 2026-04-20
closed · Rounds: 4 · Score: 0.86 · 2026-04-12
closed · Rounds: 5 · Score: 0.95 · 2026-04-12
closed · Rounds: 4 · Score: 0.95 · 2026-04-06
closed · Rounds: 4 · Score: 0.95 · 2026-04-03
closed · Rounds: 4 · Score: 0.86 · 2026-04-01
closed · Rounds: 4 · Score: 0.88 · 2026-04-01
Hypotheses and analyses mentioning COGNITIVE_DECLINE in their description or question text
Score: 0.612 · neurodegeneration · 2026-04-28
The question is likely underpowered or misleading unless analyses preserve the key strata: DPP6, GWAS. Averaging across
Score: 0.612 · neurodegeneration · 2026-04-28
The question is likely underpowered or misleading unless analyses preserve the key strata: amyloid-beta. Averaging acros
Score: 0.608 · neurodegeneration · 2026-04-28
The debate supports treating this as a validation program before ranking it as a therapy. Perturbation should move a pro
Score: 0.608 · neurodegeneration · 2026-04-28
The debate supports treating this as a validation program before ranking it as a therapy. Perturbation should move a pro