gene

SCN4B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SCN4B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

36Connections

0Hypotheses

0Analyses

16Outgoing

20Incoming

0Experiments

0Debates

Summary

Page for SCN4B Gene - Sodium Voltage-Gated Channel Beta Subunit 4

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🧬 Gene Info

Gene Symbol	SCN4B
Full Name	Sodium Voltage-Gated Channel Beta Subunit 4
Aliases	Page for SCN4B Gene, Page for SCN4B Protein
Chromosome	11q23.3
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Brain, Heart, Skeletal muscle
Molecular Weight	25 kDa
Amino Acids	228 aa
Exons	6
UniProt ID	Q9H5Q3
GeneCards	SCN4B
Human Protein Atlas	SCN4B
Brain	Highest expression in hippocampus, cerebral cortex, and cerebellum. Expressed in both excitatory neurons and inhibitory interneurons.
Heart	Strong expression in cardiac myocytes, where it modulates cardiac sodium current (INa).
Skeletal Muscle	Present in muscle fibers, contributing to neuromuscular excitability.
Associated Diseases	neurodegeneration
Interactions	ADCYAP1R1, ATP1A2, CANCER, CLDN4, GENES, NTRK2
KG Connections	36 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: SCN4B — AlphaFold Q9H5Q3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SCN4B Gene - Sodium Voltage-Gated Channel Beta Subunit 4

gene · 1049 words

→

SCN4B Protein - Sodium Channel Beta-4 Subunit

protein · 744 words

→

Pathway Diagram

graph TD
    SCN4B["SCN4B"]
    Anxiety{"Anxiety"}
    SCN4B -->|"activates"| Anxiety
    Ms{"Ms"}
    SCN4B -->|"regulates"| Ms
    Depression{"Depression"}
    SCN4B -->|"activates"| Depression
    STK4["STK4"]
    SCN4B -->|"regulates"| STK4
    neurodegeneration["neurodegeneration"]
    SCN4B -->|"implicated in"| neurodegeneration
    DNAJB12["DNAJB12"]
    DNAJB12 -->|"regulates"| SCN4B
    RB1CC1["RB1CC1"]
    RB1CC1 -->|"regulates"| SCN4B
    style SCN4B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (16)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:SCN4B	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Cancer	biomarker_for	disease	0.65
Ms	regulates	disease	0.65
Depression	activates	disease	0.65
Anxiety	activates	disease	0.65
SLC17A7	associated_with	gene	0.60
App	biomarker_for	protein	0.60
STK4	regulates	gene	0.60
CLDN4	associated_with	gene	0.60
NTRK2	associated_with	gene	0.60
ATP1A2	associated_with	gene	0.60
ATP1A2	interacts_with	gene	0.50
NTRK2	interacts_with	gene	0.50
SLC17A7	co_discussed	protein	0.50
SLC17A7	interacts_with	protein	0.50

Incoming (20)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:SCN4B	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
CLDN4	interacts_with	gene	0.60
ADCYAP1R1	interacts_with	gene	0.60
GENES	associated_with	gene	0.60
CLDN4	associated_with	gene	0.60
AND	associated_with	gene	0.60
HUB GENES	biomarker_for	gene	0.60
CANCER	biomarker_for	gene	0.60
SLC17A7	associated_with	gene	0.60
ATP1A2	associated_with	gene	0.60
NTRK2	associated_with	gene	0.60
DNAJB12	regulates	gene	0.60
RB1CC1	regulates	gene	0.60
ATP1A2	interacts_with	gene	0.60
NTRK2	interacts_with	gene	0.60
NTRK2	co_discussed	gene	0.50
CANCER	activates	gene	0.50
GENES	activates	gene	0.50
WAS	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SCN4B in their description or question text

No additional research found