Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about EPILEPTOGENESIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | EPILEPTOGENESIS |
graph TD
EPILEPTOGENESIS[EPILEPTOGENESIS]
EPILEPTOGENESIS -->|contributes to| Tuberous_Sclerosis_Complex_Ass[Tuberous Sclerosis Complex Associated Epilepsy]
Tuberous_Sclerosis_Complex[Tuberous Sclerosis Complex] -->|causes| EPILEPTOGENESIS
MTOR[MTOR] -->|regulates| EPILEPTOGENESIS
HCN1[HCN1] -->|implicated in| EPILEPTOGENESIS
GABAergic_Dysfunction[GABAergic Dysfunction] -->|contributes to| EPILEPTOGENESIS
PARP14[PARP14] -->|implicated in| EPILEPTOGENESIS
Neuroinflammation[Neuroinflammation] -->|involved_in| EPILEPTOGENESIS
Abnormal_Connectivity[Abnormal Connectivity] -->|contributes to| EPILEPTOGENESIS
Decreased_Hcn1_Expression[Decreased Hcn1 Expression] -->|contributes to| EPILEPTOGENESIS| Target | Relation | Type | Str |
|---|---|---|---|
| Tuberous Sclerosis Complex Associated Epilepsy | contributes_to | disease | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Tuberous Sclerosis Complex | causes | disease | 0.95 |
| HCN1 | associated_with | gene | 0.95 |
| MTOR | regulates | gene | 0.95 |
| HCN1 | implicated_in | entity | 0.85 |
| Neuroinflammation | involved_in | process | 0.85 |
| GABAergic Dysfunction | contributes_to | mechanism | 0.85 |
| PARP14 | implicated_in | gene | 0.85 |
| MTOR | involved_in | gene | 0.85 |
| decreased Ih current | risk_factor_for | phenotype | 0.80 |
| Decreased Hcn1 Expression | contributes_to | mechanism | 0.80 |
| Abnormal Connectivity | contributes_to | mechanism | 0.80 |
| neuroinflammation | activates | process | 0.70 |
| TNF | activates | protein | 0.70 |
| P2RY1 | contributes_to | gene | 0.60 |
| SLC17A7 | implicated_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning EPILEPTOGENESIS in their description or question text
No additional research found