Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FOXO3A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | FOXO3A |
| Key Genes/Proteins | AKT, AMPK, HIF1A, POLRMT, SIRT3 |
| Related Diseases | ferroptosis, Longevity, Microglia Phenotype |
graph TD
FOXO3A["FOXO3A"]
FOXO3A -->|"interacts"| SIRT3["SIRT3"]
FOXO3A -->|"interacts"| POLRMT["POLRMT"]
FOXO3A -->|"regulates"| autophagy["autophagy"]
FOXO3A -->|"inhibits"| inflammation["inflammation"]
FOXO3A -->|"inhibits"| ferroptosis["ferroptosis"]
FOXO3A -->|"regulates"| mitochondria["mitochondria"]
FOXO3A -->|"regulates"| HIF1A["HIF1A"]
calycosin["calycosin"] -->|"regulates"| FOXO3A
STAT3["STAT3"] -->|"regulates"| FOXO3A
AKT["AKT"] -->|"phosphorylates"| FOXO3A
AMPK["AMPK"] -->|"activates"| FOXO3A
PI3K_AKT_pathway["PI3K/AKT pathway"] -->|"activates"| FOXO3A
PI3K["PI3K"] -->|"activates"| FOXO3A
trifluoperazine["trifluoperazine"] -->|"activates"| FOXO3A| Target | Relation | Type | Str |
|---|---|---|---|
| SIRT3 | interacts_with | protein | 0.90 |
| POLRMT | interacts_with | protein | 0.90 |
| Mitophagy | regulates | process | 0.85 |
| Neuroinflammation | involved_in | process | 0.85 |
| Microglia Phenotype | regulates | phenotype | 0.85 |
| autophagy | regulates | pathway | 0.80 |
| Longevity | associated_with | phenotype | 0.80 |
| inflammation | inhibits | process | 0.70 |
| ferroptosis | inhibits | phenotype | 0.64 |
| mitochondria | regulates | cell_type | 0.64 |
| HIF1A | regulates | protein | 0.56 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AKT | phosphorylates | protein | 0.85 |
| SIRT3 | activates | gene | 0.85 |
| calycosin | regulates | drug | 0.80 |
| AMPK | regulates | protein | 0.80 |
| STAT3 | regulates | protein | 0.80 |
| AMPK | interacts_with | protein | 0.80 |
| AKT | phosphorylates | gene | 0.80 |
| AMPK | activates | protein | 0.72 |
| PI3K/AKT pathway | activates | pathway | 0.70 |
| AKT | activates | protein | 0.70 |
| PI3K | activates | pathway | 0.70 |
| trifluoperazine | activates | drug | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning FOXO3A in their description or question text
No additional research found