Contents

SIRT3 - Sirtuin 3

🧬 Gene Info

Gene Symbol	SIRT3
Full Name	Sirtuin 3
Aliases	Page for SIRT3, Page for SIRT3 Protein
Chromosome	11p15.5
Protein Type	Enzyme
Target Class	Enzyme
Function	SIRT3 is the primary mitochondrial deacetylase, regulating key metabolic enzymes and proteins involved in
Mechanism of Action	Enzyme activation — enhancing SIRT3 deacetylase activity restores mitochondrial protein function and reduces oxidative stress
Subcellular Localization	mitochondria. It plays a critical role in regulating mitochondrial function, metabolism, and cellular stress responses
Druggability	Medium (0.61)
Clinical Stage	Phase II
Molecular Weight	44 kDa
Amino Acids	25 aa
Pathways	Akt, Angiogenesis, Apoptosis, Autophagy, Mtor
UniProt ID	Q9NWU1
NCBI Gene ID	23410
Ensembl ID	ENSG00000142092
OMIM	604479
GeneCards	SIRT3
Human Protein Atlas	SIRT3
Associated Diseases	aging, ALS, Alzheimer, alzheimer_s_disease
Known Drugs/Compounds	Aloe-emodin, Epigallocatechin gallate, Epigallocatechin Gallate, Honokiol, METFORMIN, Nad
Interactions	ACOX1, Actin, Adiponectin, ADIPOQ, AGING, AKT
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	SIRT3-Mediated Mitochondrial Deacetylation Failure Mitochondrial-Nuclear Epigenetic Cross-Talk Restor SIRT3 gates microglial surveillance versus primed
KG Connections	1142 knowledge graph edges
Databases	GeneCards HPA STRING

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