concept

MITOCHONDRIAL QUALITY CONTROL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MITOCHONDRIAL QUALITY CONTROL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

62Connections

1Hypotheses

2Analyses

15Outgoing

47Incoming

0Experiments

3Debates

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💡 Concept Info

Name	MITOCHONDRIAL QUALITY CONTROL

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Mitochondrial Quality Control in Neurons

cell · 649 words

→

Pathway Diagram

graph TD
    MITOCHONDRIAL_QUALITY_CONTROL["MITOCHONDRIAL QUALITY CONTROL"]
    MITOCHONDRIAL_QUALITY_CONTROL -->|"regulates"| Neuronal_Survival["Neuronal Survival"]
    MITOCHONDRIAL_QUALITY_CONTROL -->|"regulates"| Mitochondrial_Dysfunction["Mitochondrial Dysfunction"]
    MITOCHONDRIAL_QUALITY_CONTROL -.protects against.-> Intervertebral_Disc_Degenerati["Intervertebral Disc Degeneration"]
    MITOCHONDRIAL_QUALITY_CONTROL -.protects against.-> Osteoarthritis["Osteoarthritis"]
    PINK1_Parkin_pathway["PINK1-Parkin pathway"] -->|"regulates"| MITOCHONDRIAL_QUALITY_CONTROL
    PRKN["PRKN"] -->|"regulates"| MITOCHONDRIAL_QUALITY_CONTROL
    Mitochondrial_Derived_Vesicles["Mitochondrial-Derived Vesicles"] -->|"involved_in"| MITOCHONDRIAL_QUALITY_CONTROL
    PINK1_PRKN_Pathway["PINK1-PRKN Pathway"] -->|"involved_in"| MITOCHONDRIAL_QUALITY_CONTROL
    Organelle_Specific_Autophagy["Organelle-Specific Autophagy"] -->|"mediates"| MITOCHONDRIAL_QUALITY_CONTROL
    mitophagy["mitophagy"] -->|"promotes"| MITOCHONDRIAL_QUALITY_CONTROL
    SIRT3["SIRT3"] -->|"regulates"| MITOCHONDRIAL_QUALITY_CONTROL
    PARKIN["PARKIN"] -->|"regulates"| MITOCHONDRIAL_QUALITY_CONTROL

Outgoing (15)

Target	Relation	Type	Str
Mitochondrial Replacement Therapy	inhibits	mechanism	0.95
Exogenous Mitochondria	degrades	process	0.90
Neuronal Survival	regulates	phenotype	0.90
Mitochondrial Homeostasis	associated_with	phenotype	0.87
Hair Cell Survival	promotes	phenotype	0.85
Intervertebral Disc Degeneration	therapeutic_target	disease	0.85
ALS	associated_with	disease	0.85
Alzheimer'S Disease	associated_with	disease	0.85
Parkinson's Disease	involved_in	disease	0.85
Neuronal Homeostasis	regulates	phenotype	0.85
Mitochondrial Dysfunction	regulates	process	0.85
Intervertebral Disc Degeneration	protects_against	disease	0.80
Osteoarthritis	protects_against	disease	0.80
Neuron	expressed_in	cell_type	0.80
Social Cognition	mediates	phenotype	0.75

Incoming (47)

Source	Relation	Type	Str
PRKN	regulates	protein	0.95
PRKN	regulates	gene	0.95
PINK1-Parkin pathway	regulates	pathway	0.95
Organelle-Specific Autophagy	mediates	process	0.95
mitophagy	promotes	process	0.95
Mitophagy	associated_with	process	0.95
Mitophagy	contributes_to	process	0.95
Mitochondrial-Derived Vesicles	involved_in	process	0.95
PINK1-PRKN Pathway	involved_in	pathway	0.95
PARKIN	involved_in	gene	0.95
PINK1	involved_in	gene	0.95
MFN2	involved_in	gene	0.95
PINK1-Parkin Pathway	mediates	pathway	0.95
Parkin	involved_in	protein	0.95
Alpha-Synuclein	modulates	protein	0.95
SIRT3	regulates	gene	0.95
PARKIN	regulates	protein	0.94
PINK1-Parkin signaling	regulates	pathway	0.92
mitochondrial-derived vesicle biogenesis	promotes	process	0.92
Mitochondrial-Derived Vesicles	mediates	structure	0.92
PINK1	regulates	gene	0.90
AMPK activation	modulates	process	0.90
MIRO1	involved_in	entity	0.90
PINK1/Parkin signaling pathway	regulates	pathway	0.90
decaBDE	inhibits	compound	0.90
BOK	involved_in	protein	0.90
mitochondrial-derived vesicles	regulates	process	0.90
SIRT1	promotes	gene	0.90
SIRT1	regulates	protein	0.90
SIRT1	mediates	protein	0.90
SIRT3	regulates	gene	0.90
SIRT1	regulates	gene	0.90
NRF2	regulates	gene	0.88
mitophagy	involved_in	process	0.88
AMPK	involved_in	protein	0.85
AMPK	regulates	protein	0.85
PRKN	involved_in	gene	0.85
PINK1	associated_with	gene	0.80
Ketone Esters	associated_with	compound	0.80
cAMP/PKA signaling	regulates	pathway	0.80
HUNTINGTON	impairs	disease	0.80
NAD+ depletion	impairs	biomarker	0.70
TFEB	regulates	protein	0.70
mitophagy	regulates	process	0.70
SIRT3	participates_in	gene	0.68
PRKN	involved_in	gene	0.60
PINK1	involved_in	protein	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK	0.738	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di

Mentioning Analyses (2)

Scientific analyses that reference this entity

Clinical Trial Landscaping for Alzheimer's Disease Therapeutics

neurodegeneration | 2026-04-16 | 0 hypotheses

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

neurodegeneration | 2026-04-03 | 18 hypotheses Top: 0.847

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Transcriptomic cytoarchitecture reveals principles of human neocortex organizati [PMID:37824655]	Jorstad NL, Close J, Johansen N, Yanny A	Science	2023	186
Targeted nanovesicular delivery of dexmedetomidine modulates microglial lysosoma [PMID:41778730]	Zhang Y, Jiang H, Zhang F, Liao J	Neural regeneration research	2026	0
The myocardial ischemic cascade network and multi-target synergistic interventio [PMID:41544859]	Qi L, Yi J, Shen Y, Jiang H, Yao X et al	Biochem Pharmacol	2026	0
Homoplantaginin ameliorates osteoarthritis by activating Sirt3/PINK1/Parkin sign [PMID:41720004]	Zhang H, Xiao J, Yi Y, Chen B, Lv W et a	Phytomedicine	2026	0
Kakkalide promotes spinal cord injury repair by regulating microglial M2 polariz [PMID:41720005]	You T, Dai B, Ding X, He Z, Peng J et al	Phytomedicine	2026	0
Interaction of mtROS-Immune-Inflammatory Vicious Cycle Activation in Sepsis-Indu [PMID:41905969]	Wang Y, Yuan Q	Clin Exp Pharmacol Physiol	2026	0
Metformin attenuates HSV-1-induced neuropathic pain by restoring Sirt3-mediated [PMID:41896899]	Yuanyuan Fang; Mengqiu Deng; Kesheng Hua	Cell communication and signali	2026	0
Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via P [PMID:41906653]	Xu Z, Cui X, Chu H, Wan H, Xie Y, Wang Y	Journal of diabetes	2026	0
Inhibition of mitochondrial ROS turns LC3-associated phagocytosis to autophagy u [PMID:41896101]	Cheng YL, Su MS, Liao CC, Chang TW, Hsie	Journal of microbiology, immun	2026	0
Hyperoside stabilizes ACAT1 to promote fatty acid oxidation and attenuate kidney [PMID:41903436]	Shan C, Szili-Torok T, Yue G, Zhang L, M	Phytomedicine : international	2026	0
Melatonin Ameliorates decaBDE-Induced Autism-Relevant Behaviors Through Promotin [PMID:41897550]	["Gao L", "Shen J", "Gao J", "Li T", "Ya	Antioxidants (Basel, Switzerla	2026	0
Sirtuins as mediators and targets of arsenic toxicity: unraveling signaling path [PMID:40844627]	El-Mahrouk SR, El-Kadi AOS	Archives of toxicology	2025	0
Targeted activation of ErbB4 receptor ameliorates neuronal deficits and neuroinf [PMID:40089796]	Liu C, Zhao Y, Zhang W, Dao JJ, Li Q, Hu	Journal of neuroinflammation	2025	0
Phenylpropanoids of Eleutherococcus senticosus (Rupr. & maxim.) maxim. Alleviate [PMID:40081261]	Yang R, Meng X, Zhao W, Xu SQ, Wang SY,	Bioorganic chemistry	2025	0
Small molecule DDQ involvement of ERK-mediated signaling pathway with enhanced m [PMID:40222458]	Pradeepkiran JA, Kshirsagar S, Alvir RV,	Biochimica et biophysica acta.	2025	0
The effects of Honokiol on the liver of Alzheimer's disease mice by upregulating [PMID:40776632]	Wang H, Liu J, Tian YR, Zhu F, Li H	Journal of Alzheimer's disease	2025	0
Publisher Correction: Age and sex affect deep learning prediction of cardiometab [PMID:33414494]	Gerrits, Elen, Van Craenendonck, Trianta	Scientific Reports	2021	0
The human olfactory system in two proteinopathies: Alzheimer's and Parkinson's d [PMID:32493457]	Ubeda-Bañon I, Saiz-Sanchez D, Flores-Cu	Translational neurodegeneratio	2020	0
Diagnostic delays in Middle East respiratory syndrome coronavirus patients and h [PMID:31006635]	Ahmed AE	Journal of infection and publi	2019	0
Homeostatic Control of Hpo/MST Kinase Activity through Autophosphorylation-Depen [PMID:29262338]	Zheng Y, Liu B, Wang L, Lei H, Pulgar Pr	Cell reports	2017	0

Debates (3)

Multi-agent debates referencing this entity

What is the current clinical trial landscape for AD therapeutics, and which mech

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Is the amyloid concentration in AD clinical trials rational given lecanemab's ap

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

What cell types are most vulnerable in Alzheimers Disease based on SEA-AD transc

closed · Rounds: 4 · Score: 0.90 · 2026-04-03