gene

ERBB4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ERBB4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

129Connections

0Hypotheses

0Analyses

50Outgoing

46Incoming

0Experiments

0Debates

Summary

ERBB4 is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with Aging, Als, Alzheimer. Connected to 74 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	ERBB4
Chromosome	2q34
Protein Family	EGFR/ERBB family
Protein Type	Receptor
Function	Binds neuregulin (NRG) ligands
Primary Expression	dopaminergic neurons - Neuregulin protection studies - May affect LRRK2 signaling - Neurotrophic factor connections - Gene variants
Molecular Weight	180 kDa
Amino Acids	1308 aa
Pathways	PI3K, MAPK
UniProt ID	Q15303
NCBI Gene ID	2065
Ensembl ID	ENSG00000178668
GeneCards	ERBB4
Human Protein Atlas	ERBB4
Associated Diseases	Als, Alzheimer
Interactions	ADRA1A, ADRA2A, ADRB1, AKT, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections	121 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ERBB4 — AlphaFold Q15303 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ERBB4 Gene

gene · 757 words

→

Pathway Diagram

graph TD
    ERBB4["ERBB4"]
    Alzheimer{"Alzheimer"}
    ERBB4 -->|"inhibits"| Alzheimer
    ERBB4 -->|"activates"| Alzheimer
    Aging{"Aging"}
    ERBB4 -->|"activates"| Aging
    Depression{"Depression"}
    ERBB4 -->|"activates"| Depression
    Cardiovascular{"Cardiovascular"}
    ERBB4 -->|"activates"| Cardiovascular
    Epilepsy{"Epilepsy"}
    ERBB4 -->|"activates"| Epilepsy
    Schizophrenia{"Schizophrenia"}
    ERBB4 -->|"activates"| Schizophrenia
    Ms{"Ms"}
    ERBB4 -->|"activates"| Ms
    Als{"Als"}
    ERBB4 -->|"inhibits"| Als
    Anxiety{"Anxiety"}
    ERBB4 -->|"inhibits"| Anxiety
    ERBB4 -->|"inhibits"| Schizophrenia
    ERBB4 -->|"inhibits"| Ms
    NRG1["NRG1"]
    NRG1 -->|"contributes to"| ERBB4
    NRG1 -->|"activates"| ERBB4
    DISC1["DISC1"]
    DISC1 -->|"inhibits"| ERBB4
    MIRNAS["MIRNAS"]
    MIRNAS -->|"regulates"| ERBB4
    RELN["RELN"]
    RELN -->|"regulates"| ERBB4
    MYC["MYC"]
    MYC -->|"regulates"| ERBB4
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"activates"| ERBB4
    DISC1 -->|"associated with"| ERBB4
    NRG1 -->|"associated with"| ERBB4
    AMYLOID["AMYLOID"]
    AMYLOID -->|"inhibits"| ERBB4
    ALZHEIMER_S_DISEASE -->|"inhibits"| ERBB4
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"inhibits"| ERBB4
    style ERBB4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (83)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ERBB4	data_in	dataset_row	0.00
neuronal injury	regulates	process	0.95
TLR4-NF-κB-NLRP3	inhibits	pathway	0.90
Inflammation	activates	disease	0.85
SIRT3	upstream_of	gene	0.85
DOCK3	upstream_of	gene	0.85
mitochondrial dysfunction	prevents	process	0.85
Neuroinflammation	activates	disease	0.75
Als	activates	disease	0.75
Nf-Κb	activates	pathway	0.70
NEUROINFLAMMATION	activates	gene	0.70
Cancer	regulates	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	regulates	disease	0.65
Als	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	inhibits	disease	0.65
Epilepsy	activates	disease	0.65
Schizophrenia	activates	disease	0.65
Ms	activates	disease	0.65
Alzheimer	activates	disease	0.65
Als	inhibits	disease	0.65
Anxiety	inhibits	disease	0.65
Schizophrenia	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Aging	activates	disease	0.65
Depression	activates	disease	0.65
Cardiovascular	activates	disease	0.65
NRG1	mediates	entity	0.60
FOSB	expressed_in	gene	0.60
CFOS	expressed_in	gene	0.60
BDNF	expressed_in	gene	0.60
Rb	expressed_in	protein	0.60
Amyloid	activates	pathway	0.60
Synaptic Transmission	activates	pathway	0.60
GENES	inhibits	gene	0.60
Amyloid	inhibits	pathway	0.60
PI3K	phosphorylates	gene	0.60
NNMT	activates	gene	0.60
PI3K	activates	gene	0.60
NRG1	interacts_with	gene	0.60
IL1RL1	interacts_with	gene	0.60
IL33	interacts_with	gene	0.60
Long-Term Potentiation	expressed_in	pathway	0.60
AMYLOID	inhibits	gene	0.60
Interneuron	activates	cell_type	0.60
Neuron	activates	cell_type	0.60
cortex	expressed_in	brain_region	0.60
ALS	associated_with	disease	0.60
GLUD1	inhibits	gene	0.60

Incoming (46)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ERBB4	data_in	dataset_row	0.00
E4A	activates	drug	0.95
NRG1	interacts_with	gene	0.90
INFLAMMATION	activates	gene	0.80
NF-ΚB	activates	gene	0.70
NLRP3	activates	gene	0.70
TLR4	activates	gene	0.70
DOCK3	activates	gene	0.70
SIRT3	activates	gene	0.70
ADRA2A	interacts_with	gene	0.60
DBH	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
EPILEPSY	activates	gene	0.60
GENES	inhibits	gene	0.60
AND	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
CGAS	activates	gene	0.60
STING	activates	gene	0.60
AKT	activates	gene	0.60
APP	activates	gene	0.60
CDK5	activates	gene	0.60
NRG1	regulates	gene	0.60
ADRA1A	interacts_with	gene	0.60
ADRB1	interacts_with	gene	0.60
DISC1	inhibits	gene	0.60
RELN	regulates	gene	0.60
MYC	regulates	gene	0.60
NRG1	activates	gene	0.60
GABA	activates	gene	0.60
AKT	phosphorylates	gene	0.60
AMYLOID	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
APP/PS1	activates	gene	0.60
AMYLOID	activates	gene	0.60
ALZHEIMER'S DISEASE	contributes_to	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
AND	inhibits	gene	0.60
GLUD1	inhibits	gene	0.60
EXERCISE	regulates	gene	0.60
MIRNAS	regulates	gene	0.60
NRG1	associated_with	gene	0.60
DISC1	associated_with	gene	0.60
NRG1	inhibits	gene	0.60
SCHIZOPHRENIA	inhibits	disease	0.50
NRG1	expressed_in	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ERBB4 in their description or question text

No additional research found