Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ALOE-EMODIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | ALOE-EMODIN |
graph TD
ALOE_EMODIN["ALOE-EMODIN"]
ALOE_EMODIN -->|"activates"| Mitophagy["Mitophagy"]
ALOE_EMODIN -->|"activates"| AMPK_PGC_1__SIRT3_Signaling_Pa["AMPK/PGC-1alpha/SIRT3 Signaling Pathway"]
ALOE_EMODIN -->|"activates"| Ampk_Pgc_1__Sirt3_Signaling_Pa["Ampk/Pgc-1Alpha/Sirt3 Signaling Pathway"]
ALOE_EMODIN -->|"activates"| AMPK_PGC_1__SIRT3_signaling_pa["AMPK/PGC-1alpha/SIRT3 signaling pathway"]
ALOE_EMODIN -->|"treats"| Alzheimer_s_Disease["Alzheimer's Disease"]
ALOE_EMODIN -->|"treats"| Cognitive_Dysfunction["Cognitive Dysfunction"]| Target | Relation | Type | Str |
|---|---|---|---|
| AMPK/PGC-1α/SIRT3 Signaling Pathway | activates | pathway | 0.95 |
| Ampk/Pgc-1Α/Sirt3 Signaling Pathway | activates | pathway | 0.95 |
| AMPK/PGC-1α/SIRT3 signaling pathway | activates | pathway | 0.95 |
| Mitophagy | activates | process | 0.95 |
| Alzheimer's Disease | treats | disease | 0.90 |
| Alzheimer's Disease | protects_against | disease | 0.90 |
| Hippocampal Damage | associated_with | phenotype | 0.90 |
| Alzheimer'S Disease | treats | disease | 0.90 |
| Cognitive Dysfunction | treats | phenotype | 0.90 |
| Hippocampal Neurons | protects_against | cell_type | 0.85 |
| Neuronal Damage | protects_against | phenotype | 0.85 |
| Alzheimer's disease | treats | disease | 0.80 |
| liver fibrosis | treats | disease | 0.70 |
| Type 2 diabetes | treats | disease | 0.70 |
| hepatotoxicity | causes | process | 0.70 |
| nephrotoxicity | causes | process | 0.70 |
| mitophagy | activates | process | 0.70 |
| Alzheimer's disease | treats | disease | 0.70 |
| AMPK | activates | protein | 0.70 |
| PPARGC1A | activates | protein | 0.70 |
| SIRT3 | activates | protein | 0.70 |
| inflammation | protects_against | process | 0.70 |
| AMPK | activates | protein | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Rhubarb | associated_with | compound | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ALOE-EMODIN in their description or question text
No additional research found