protein

HAPLN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HAPLN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

25Connections

0Hypotheses

0Analyses

17Outgoing

8Incoming

0Experiments

0Debates

Summary

Page for HAPLN1 Protein

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🔬 Protein Info

Gene Symbol	HAPLN1
Full Name	Hyaluronan and Proteoglycan Link Protein 1
Chromosome	19q13.12
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	40 kDa
UniProt ID	P10915
GeneCards	HAPLN1
Human Protein Atlas	HAPLN1
Associated Diseases	Als, Inflammation, Neuroinflammation, Ptsd
KG Connections	25 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: HAPLN1 — AlphaFold P10915 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HAPLN1 Gene

gene · 721 words

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HAPLN1 Protein

protein · 545 words

→

Pathway Diagram

graph TD
    HAPLN1["HAPLN1"]
    Als{"Als"}
    HAPLN1 -->|"associated_with"| Als
    Neuroinflammation{"Neuroinflammation"}
    HAPLN1 -->|"associated_with"| Neuroinflammation
    ALS{"ALS"}
    HAPLN1 -->|"associated_with"| ALS
    Inflammation{"Inflammation"}
    HAPLN1 -->|"associated_with"| Inflammation
    Ptsd{"Ptsd"}
    HAPLN1 -->|"associated_with"| Ptsd
    CCR5(["CCR5"])
    HAPLN1 -->|"associated_with"| CCR5
    CDH23(["CDH23"])
    CDH23 -->|"associated_with"| HAPLN1
    GRM2(["GRM2"])
    GRM2 -->|"associated_with"| HAPLN1
    MITOCHONDRIA(["MITOCHONDRIA"])
    MITOCHONDRIA -->|"associated_with"| HAPLN1
    GENES(["GENES"])
    GENES -->|"associated_with"| HAPLN1
    style HAPLN1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (17)

Target	Relation	Type	Str
ALS	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Ptsd	associated_with	disease	0.65
Als	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
GRM2	associated_with	gene	0.60
Chemokine	associated_with	protein	0.60
Oxidative Phosphorylation	associated_with	pathway	0.60
MITOCHONDRIA	associated_with	gene	0.60
P2RY12	associated_with	gene	0.60
CDH23	associated_with	gene	0.60
CCR5	associated_with	gene	0.60
Hippocampus	expressed_in	brain_region	0.55
Cerebellum	expressed_in	brain_region	0.55
Cortex	expressed_in	brain_region	0.55
Amygdala	expressed_in	brain_region	0.55
GLUTAMATE	associated_with	concept	0.50

Incoming (8)

Source	Relation	Type	Str
CDH23	associated_with	gene	0.60
GRM2	associated_with	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
GENES	associated_with	gene	0.60
NEUROINFLAMMATION	associated_with	gene	0.60
P2RY12	associated_with	gene	0.60
CCR5	associated_with	gene	0.60
P2Y12	associated_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HAPLN1 in their description or question text

No additional research found