concept

MAST CELL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAST CELL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

121Connections

0Hypotheses

0Analyses

23Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

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💡 Concept Info

Name	MAST CELL
Key Genes/Proteins	ACHE, FGF
Related Diseases	ALZHEIMER'S, NEURODEGENERATION, STROKE

Pathway Diagram

graph TD
    MAST_CELL["MAST CELL"]
    MAST_CELL -->|"causes"| STROKE["STROKE"]
    MAST_CELL -->|"causes"| T_CELL["T CELL"]
    MAST_CELL -->|"activates"| T_CELLS["T CELLS"]
    MAST_CELL -->|"contributes to"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    MAST_CELL -->|"contributes to"| NEURON["NEURON"]
    STROKE -->|"activates"| MAST_CELL
    IL_33["IL-33"] -->|"activates"| MAST_CELL
    TSLP["TSLP"] -->|"activates"| MAST_CELL
    CYTOKINES["CYTOKINES"] -->|"target for"| MAST_CELL
    ALZHEIMER["ALZHEIMER"] -->|"activates"| MAST_CELL
    CRH["CRH"] -->|"activates"| MAST_CELL
    AMYLOID["AMYLOID"] -->|"activates"| MAST_CELL
    PARKINSON["PARKINSON"] -->|"activates"| MAST_CELL

Outgoing (23)

Target	Relation	Type	Str
NEURON	activates	cell_type	0.65
NEUTROPHIL	contributes_to	cell_type	0.65
T CELL	associated_with	cell_type	0.65
STROKE	causes	disease	0.60
T CELL	causes	cell_type	0.60
STROKE	activates	disease	0.60
T CELL	activates	cell_type	0.60
T CELLS	activates	cell_type	0.60
NEURON	contributes_to	cell_type	0.60
T CELLS	causes	cell_type	0.60
T CELLS	associated_with	cell_type	0.60
T CELL	targets	cell_type	0.60
T CELLS	targets	cell_type	0.60
T CELL	expressed_in	cell_type	0.60
T CELLS	expressed_in	cell_type	0.60
NEURODEGENERATION	associated_with	disease	0.60
Thalamus	expressed_in	brain_region	0.50
Hypothalamus	expressed_in	brain_region	0.50
NEUTROPHIL	co_discussed	cell_type	0.40
MICROGLIA	co_discussed	cell_type	0.40
THALAMUS	co_discussed	brain_region	0.40
T CELL	co_discussed	cell_type	0.40
T CELLS	co_discussed	cell_type	0.40

Incoming (98)

Source	Relation	Type	Str
MACROPHAGE	contributes_to	cell_type	0.65
ALZHEIMER	activates	gene	0.60
AMYLOID	activates	gene	0.60
PARKINSON	activates	gene	0.60
CYTOKINES	activates	gene	0.60
STROKE	activates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AGING	activates	gene	0.60
AMYLOID	associated_with	gene	0.60
MICROGLIA	regulates	gene	0.60
TAK1	activates	gene	0.60
SMAD4	activates	gene	0.60
TNF	activates	gene	0.60
IL20	activates	gene	0.60
CXCL8	activates	gene	0.60
STAT3	activates	gene	0.60
IL6	activates	gene	0.60
IL-33	activates	gene	0.60
TSLP	activates	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
ACHE	activates	gene	0.60
ALZHEIMER'S	expressed_in	disease	0.60
CRH	activates	gene	0.60
CRH	regulates	gene	0.60
TAU	activates	gene	0.60
APP	activates	gene	0.60
CERS2	activates	gene	0.60
SPTLC1	activates	gene	0.60
BMP	causes	gene	0.60
IL-1	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
ASTROCYTES	associated_with	gene	0.60
COMPLEMENT	therapeutic_target	gene	0.60
MICROGLIA	associated_with	gene	0.60
DEPRESSION	activates	gene	0.60
BDNF	contributes_to	gene	0.60
NGF	contributes_to	gene	0.60
GDNF	contributes_to	gene	0.60
TSLP	expressed_in	gene	0.55
Fibrosis	activates	disease	0.55
AND	expressed_in	gene	0.55
CYTOKINES	expressed_in	gene	0.55
Neuroinflammation	therapeutic_target	disease	0.55
IL-33	expressed_in	gene	0.55
FGF	expressed_in	gene	0.55
AUTOPHAGY	expressed_in	gene	0.55
APOPTOSIS	expressed_in	gene	0.55
STROKE	expressed_in	gene	0.55
BRAIN INFLAMMATION	expressed_in	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAST CELL in their description or question text

No additional research found