Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ALCOHOL USE DISORDER: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | ALCOHOL USE DISORDER |
graph TD
ALCOHOL_USE_DISORDER[ALCOHOL USE DISORDER]
ALCOHOL_USE_DISORDER -->|causes| Compulsive_Alcohol_Consumption[Compulsive Alcohol Consumption]
Central_Amygdala_CRF_Expressin[Central Amygdala CRF-Expressing Neurons] -->|involved_in| ALCOHOL_USE_DISORDER
HCRT[HCRT] -->|implicated in| ALCOHOL_USE_DISORDER
Crf_Neurons[Crf Neurons] -->|implicated in| ALCOHOL_USE_DISORDER
BNST[BNST] -->|implicated in| ALCOHOL_USE_DISORDER
Arousal_Dysfunction[Arousal Dysfunction] -->|contributes to| ALCOHOL_USE_DISORDER
HCRT_signaling_pathway[HCRT signaling pathway] -->|target for| ALCOHOL_USE_DISORDER
CENTRAL_AMYGDALA[CENTRAL AMYGDALA] -->|regulates| ALCOHOL_USE_DISORDER
chromatin_remodeling[chromatin remodeling] -->|activates| ALCOHOL_USE_DISORDER
gene_expression[gene expression] -->|activates| ALCOHOL_USE_DISORDER| Target | Relation | Type | Str |
|---|---|---|---|
| Compulsive Alcohol Consumption | causes | phenotype | 0.95 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Post-Traumatic Stress Disorder | associated_with | disease | 0.95 |
| PTSD | associated_with | disease | 0.95 |
| Central Amygdala CRF-Expressing Neurons | involved_in | cell_type | 0.90 |
| HCRT | implicated_in | gene | 0.90 |
| Crf Neurons | implicated_in | cell_type | 0.90 |
| Crf Neurons | involved_in | cell_type | 0.88 |
| Arousal Dysfunction | contributes_to | phenotype | 0.85 |
| BNST | implicated_in | brain_region | 0.85 |
| HCRT signaling pathway | therapeutic_target | pathway | 0.85 |
| CENTRAL AMYGDALA | regulates | anatomical_region | 0.80 |
| oxidative stress | associated_with | process | 0.70 |
| gene expression | activates | process | 0.70 |
| alcohol | causes | drug | 0.70 |
| chromatin remodeling | activates | process | 0.70 |
| IL18 | associated_with | gene | 0.65 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ALCOHOL USE DISORDER in their description or question text
No additional research found