gene

CDH23

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CDH23: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

35Connections

0Hypotheses

0Analyses

28Outgoing

7Incoming

0Experiments

0Debates

Summary

Page for CDH23 Gene

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🧬 Gene Info

Gene Symbol	CDH23
Full Name	Cadherin 23
Chromosome	10q22.1
Function	encodes a member of the cadherin superfamily of calcium-dependent cell adhesion molecules.
Primary Expression	photoreceptors:
Amino Acids	654 aa
UniProt ID	Q9Y6M7
NCBI Gene ID	64061
Ensembl ID	ENSG00000107736
GeneCards	CDH23
Human Protein Atlas	CDH23
Domain structure	Multiple extracellular cadherin repeats (EC repeats), transmembrane domain
Calcium binding	Calcium ions between EC repeats stabilize the structure
Dimerization	Forms cis-homodimers and trans-dimers with other cadherins
Molecular size	Large protein (~3,654 amino acids)
Associated Diseases	Als, Inflammation, Neuroinflammation, Ptsd
KG Connections	35 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CDH23 — AlphaFold Q9Y6M7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CDH23 Gene

gene · 540 words

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Pathway Diagram

graph TD
    CDH23["CDH23"]
    Als["Als"]
    CDH23 -->|"associated with"| Als
    Neuroinflammation["Neuroinflammation"]
    CDH23 -->|"associated with"| Neuroinflammation
    Alzheimer["Alzheimer"]
    CDH23 -->|"therapeutic target"| Alzheimer
    Aging["Aging"]
    CDH23 -->|"therapeutic target"| Aging
    Neuroinflammation["Neuroinflammation"]
    CDH23 -->|"therapeutic target"| Neuroinflammation
    ALS["ALS"]
    CDH23 -->|"associated with"| ALS
    Inflammation["Inflammation"]
    CDH23 -->|"associated with"| Inflammation
    GRM2["GRM2"]
    CDH23 -->|"associated with"| GRM2
    MITOCHONDRIA["MITOCHONDRIA"]
    CDH23 -->|"associated with"| MITOCHONDRIA
    HAPLN1["HAPLN1"]
    CDH23 -->|"associated with"| HAPLN1
    CCR5["CCR5"]
    CDH23 -->|"associated with"| CCR5
    P2RY12["P2RY12"]
    CDH23 -->|"associated with"| P2RY12
    AMYLOID["AMYLOID"]
    CDH23 -->|"therapeutic target"| AMYLOID
    APOPTOSIS["APOPTOSIS"]
    CDH23 -->|"therapeutic target"| APOPTOSIS
    ALZHEIMER["ALZHEIMER"]
    CDH23 -->|"therapeutic target"| ALZHEIMER
    AGING["AGING"]
    CDH23 -->|"therapeutic target"| AGING
    Oxidative_Stress["Oxidative Stress"]
    CDH23 -->|"therapeutic target"| Oxidative_Stress
    Apoptosis["Apoptosis"]
    CDH23 -->|"therapeutic target"| Apoptosis
    AND["AND"]
    CDH23 -->|"associated with"| AND
    Oxidative_Phosphorylation["Oxidative Phosphorylation"]
    CDH23 -->|"associated with"| Oxidative_Phosphorylation
    GENES["GENES"]
    GENES -->|"associated with"| CDH23
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    NEUROINFLAMMATION -->|"associated with"| CDH23
    P2RY12["P2RY12"]
    P2RY12 -->|"associated with"| CDH23
    CCR5["CCR5"]
    CCR5 -->|"associated with"| CDH23
    Amygdala["Amygdala"]
    CDH23 -->|"expressed in"| Amygdala
    Cortex["Cortex"]
    CDH23 -->|"expressed in"| Cortex
    Hippocampus["Hippocampus"]
    CDH23 -->|"expressed in"| Hippocampus
    Cerebellum["Cerebellum"]
    CDH23 -->|"expressed in"| Cerebellum
    neurodegeneration["neurodegeneration"]
    CDH23 -->|"implicated in"| neurodegeneration

Outgoing (28)

Target	Relation	Type	Str
Neuroinflammation	associated_with	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Ptsd	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Als	associated_with	disease	0.65
ALS	associated_with	disease	0.65
AGING	therapeutic_target	gene	0.60
Oxidative Stress	therapeutic_target	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60
AND	associated_with	gene	0.60
Chemokine	associated_with	protein	0.60
HAPLN1	associated_with	gene	0.60
CCR5	associated_with	gene	0.60
P2RY12	associated_with	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
AMYLOID	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
Oxidative Phosphorylation	associated_with	pathway	0.60
GRM2	associated_with	gene	0.60
Cortex	expressed_in	brain_region	0.55
Hippocampus	expressed_in	brain_region	0.55
Cerebellum	expressed_in	brain_region	0.55
Amygdala	expressed_in	brain_region	0.55
P2Y12	associated_with	protein	0.50
GLUTAMATE	associated_with	concept	0.50

Incoming (7)

Source	Relation	Type	Str
P2RY12	associated_with	gene	0.60
CCR5	associated_with	gene	0.60
GENES	associated_with	gene	0.60
NEUROINFLAMMATION	associated_with	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
HAPLN1	associated_with	gene	0.60
GRM2	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CDH23 in their description or question text

No additional research found