gene 1,025 words KG: PSD95
Contents

DLG4 Gene

🧬 Gene Info
Gene SymbolPSD95
Full NameDLG4
Chromosome8p12 [@migaud1998]
Protein TypeGene
Functionis an important component in the neurobiology of neurodegenerative diseases.
PathwaysApoptosis, Astrocyte Reactivity, Dendritic Spine, Epigenetic, Long-Term Potentiation
UniProt IDP78352
NCBI Gene ID1749
Ensembl IDENSG00000132535
GeneCardsPSD95
Human Protein AtlasPSD95
Associated DiseasesAls, Alzheimer, Alzheimer's disease
Known Drugs/CompoundsCN2097, rapamycin, SYN3
InteractionsACHE, AD, ADAM10, AGING, AKT, ALZHEIMER
KG Connections632 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (30)

Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54
CYP46A1 Overexpression Gene Therapy
Score: 0.92
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.81

Related Analyses (12)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (7)

Synaptic plasticity and protein expression analysis in mPFC
exploratory · proposed · Score: 0.85
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.45
s:** - Test whether HCN1 knockout specifically in EC layer I
falsification · proposed · Score: 0.40
Proposed experiment from debate on Epigenetic clocks and bio
falsification · proposed · Score: 0.40

See Also (5)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: associated_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates

Knowledge Graph (12 edges)

PSD95 regulates BDNF
CN2097 interacts_with PSD95
SYN3 interacts_with PSD95
MMP9 expressed_in PSD95
RELA associated_with PSD95
OPA1 expressed_in PSD95
P62 associated_with PSD95
MFN2 expressed_in PSD95
MBP expressed_in PSD95
PSD95 expressed_in BDNF

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