concept

GSK-3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GSK-3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

65Connections

0Hypotheses

0Analyses

22Outgoing

43Incoming

0Experiments

0Debates

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💡 Concept Info

Name	GSK-3
Key Genes/Proteins	mTOR

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GSK_3["GSK-3"]
    GSK_3 -->|"interacts"| mTOR["mTOR"]
    GSK_3 -->|"causes"| Als["Als"]
    GSK_3 -->|"causes"| Neurodegeneration["Neurodegeneration"]
    GSK_3 -->|"causes"| Alzheimer["Alzheimer"]
    GSK_3 -->|"activates"| Depression["Depression"]
    GSK_3 -->|"inhibits"| Cancer["Cancer"]
    BCL_2["BCL-2"] -->|"causes"| GSK_3
    JNK["JNK"] -->|"interacts"| GSK_3
    BID["BID"] -->|"causes"| GSK_3
    BAD["BAD"] -->|"causes"| GSK_3
    BAX["BAX"] -->|"causes"| GSK_3
    APOPTOSIS["APOPTOSIS"] -->|"activates"| GSK_3
    TAU["TAU"] -->|"causes"| GSK_3
    AUTOPHAGY["AUTOPHAGY"] -->|"causes"| GSK_3

Outgoing (22)

Target	Relation	Type	Str
tau hyperphosphorylation	regulates	process	0.70
mTOR	interacts_with	protein	0.70
Als	causes	disease	0.60
Neurodegeneration	causes	disease	0.60
Alzheimer	causes	disease	0.60
Neurodegeneration	regulates	disease	0.60
Cancer	inhibits	disease	0.60
Alzheimer	activates	disease	0.60
Als	regulates	disease	0.60
Als	activates	disease	0.60
Depression	activates	disease	0.60
Neurodegeneration	activates	disease	0.60
Alzheimer	regulates	disease	0.60
Wnt	activates	pathway	0.55
Mitochondrial Function	activates	pathway	0.55
Apoptosis	inhibits	pathway	0.55
Autophagy	causes	pathway	0.55
Oxidative Stress	activates	pathway	0.55
Pi3K/Akt	activates	pathway	0.55
Apoptosis	activates	pathway	0.55
Pi3K/Akt	interacts_with	pathway	0.55
Jak-Stat	causes	pathway	0.55

Incoming (43)

Source	Relation	Type	Str
BCL-2	causes	gene	0.60
APOPTOSIS	activates	gene	0.60
AUTOPHAGY	causes	gene	0.60
ALZHEIMER	causes	gene	0.60
CDK5	activates	gene	0.60
BACE1	activates	gene	0.60
AKT1	activates	gene	0.60
CAPN1	activates	gene	0.60
AKT	activates	gene	0.60
PSEN2	activates	gene	0.60
MAPT	activates	gene	0.60
DEPRESSION	activates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
ROS	activates	gene	0.60
CREB	activates	gene	0.60
AMPK	activates	gene	0.60
DNA	activates	gene	0.60
ERK1/2	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
PSEN1	regulates	gene	0.60
PSEN2	regulates	gene	0.60
APP	regulates	gene	0.60
PRESENILIN-1	regulates	gene	0.60
ROCK1	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
LAMP1	regulates	gene	0.60
WNT	activates	gene	0.60
AMYLOID	regulates	gene	0.60
AMYLOID-BETA	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
APP/PS1	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
JNK	interacts_with	gene	0.60
BID	causes	gene	0.60
BAD	causes	gene	0.60
BAX	causes	gene	0.60
TAU	causes	gene	0.60
SPR	interacts_with	gene	0.60
RCAN1	activates	gene	0.60
NRF2	activates	gene	0.60
KEAP1	activates	gene	0.60
TAU	activates	gene	0.60
PP2A	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GSK-3 in their description or question text

No additional research found