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protein 2,115 words KG: PRESENILIN1
Contents

Presenilin-1

🔬 Protein Info
Gene SymbolPRESENILIN1
Chromosome14q24.2.
PathwaysCholesterol Metabolism, Amyloid, Neuroinflammatory, Complement, Cholesterol
GeneCardsPRESENILIN1
Human Protein AtlasPRESENILIN1
Associated Diseasesneurodegeneration
InteractionsALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMYLOID, Amyloid Beta, AND
KG Connections33 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (18)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.92Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.71Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72APOE Isoform Conversion Therapy
Score: 0.72Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62LRP1-Dependent Tau Uptake Disruption
Score: 0.60

Related Analyses (4)

Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archivedEpigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (3)

Adoptive transfer of TCRAβ-Tregs in AD mouse model
validation · proposed · Score: 0.90Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40Experiment Validation: In vitro ThT Assay
validation · proposed · Score: 0.40

See Also (15)

Alzheimer Indonesia
institution · KG edge: activatesPresenilin-1 (PS1)
entity · KG edge: inhibitsBACE1 (Redirect)
redirect · KG edge: inhibitsAPP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: inhibitsPackard Center for ALS Research
institution · KG edge: inhibits

Knowledge Graph (12 edges)

PRESENILIN1 involved_in Calcium Regulation
APP inhibits PRESENILIN1
BACE1 inhibits PRESENILIN1
NLRP3 inhibits PRESENILIN1
PRESENILIN1 inhibits APP
PRESENILIN1 inhibits BACE1
PRESENILIN1 inhibits Presenilin
ALZHEIMER DISEASE inhibits PRESENILIN1
ALZHEIMER inhibits PRESENILIN1
AND inhibits PRESENILIN1

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