protein

presenilin-2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about presenilin-2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

55Connections

0Hypotheses

0Analyses

37Outgoing

18Incoming

0Experiments

0Debates

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🔬 Protein Info

Gene Symbol	PRESENILIN-2
Protein Family	Presenilin family, aspartyl proteases
Function	### γ-Secretase Activity
Subcellular Localization	Endoplasmic reticulum, Golgi apparatus, mitochondria
Molecular Weight	50 kDa
Amino Acids	467 aa
Pathways	Notch, Notch signaling
UniProt ID	O00287
GeneCards	PRESENILIN-2
Human Protein Atlas	PRESENILIN-2
Nine transmembrane domains	Spanning the membrane
Aspartyl protease motif	Two conserved aspartate residues (D257, D263) in transmembrane domains 6 and 7
Large hydrophilic loop	Between transmembrane domains 6 and 7
Amyloid Precursor Protein (APP)	Generates Aβ peptides
Notch receptors	Essential for development
Associated Diseases	Alzheimer'S Disease, disease
KG Connections	12 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: presenilin-2 — AlphaFold O00287 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Presenilin-2 (PS2)

protein · 2003 words

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Pathway Diagram

graph TD
    PRESENILIN_2["PRESENILIN-2"]
    PRESENILIN_2 -->|"causes"| Alzheimer["Alzheimer"]
    PRESENILIN_2 -->|"causes"| Dementia["Dementia"]
    PRESENILIN_2 -->|"causes"| Aging["Aging"]
    PRESENILIN_2 -->|"causes"| ALS["ALS"]
    PRESENILIN_2 -->|"causes"| Als["Als"]
    PRESENILIN_2 -->|"activates"| Oxidative_Stress["Oxidative Stress"]
    PRESENILIN_2 -->|"activates"| Notch["Notch"]
    PRESENILIN_2 -->|"activates"| Apoptosis["Apoptosis"]
    GENES["GENES"] -->|"causes"| PRESENILIN_2
    AMYLOID["AMYLOID"] -->|"activates"| PRESENILIN_2
    ALZHEIMER["ALZHEIMER"] -->|"causes"| PRESENILIN_2
    PRESENILIN_1["PRESENILIN-1"] -->|"causes"| PRESENILIN_2
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"activates"| PRESENILIN_2
    PRESENILIN["PRESENILIN"] -->|"causes"| PRESENILIN_2
    AND["AND"] -->|"causes"| PRESENILIN_2
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"causes"| PRESENILIN_2

Outgoing (37)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:PRESENILIN-2	data_in	dataset_row	0.00
Alzheimer	associated_with	disease	0.65
Aging	causes	disease	0.65
Dementia	causes	disease	0.65
ALS	causes	disease	0.65
Alzheimer	causes	disease	0.65
Als	causes	disease	0.65
APOPTOSIS	activates	gene	0.60
Neuron	activates	cell_type	0.60
AMYLOID	activates	gene	0.60
AMYLOID	causes	gene	0.60
Rb	activates	protein	0.60
Amyloid Beta	activates	protein	0.60
Amyloid	causes	pathway	0.60
Oxidative Stress	activates	pathway	0.60
Notch	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
Amyloid	activates	pathway	0.60
PSEN1	causes	gene	0.60
Raf	activates	protein	0.60
App	activates	protein	0.60
Ras	causes	protein	0.60
PRESENILIN-1	causes	gene	0.60
Neuron	expressed_in	cell_type	0.55
Parietal Lobe	expressed_in	brain_region	0.55
Gray Matter	expressed_in	brain_region	0.55
PSEN2	associated_with	gene	0.50
PRESENILIN	associated_with	protein	0.50
ALZHEIMER	associated_with	gene	0.50
Alzheimer'S Disease	associated_with	disease	0.50
disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
PRESENILIN	causes	protein	0.50
ALZHEIMER	causes	gene	0.50
Alzheimer'S Disease	causes	disease	0.50
ALZHEIMER'S	causes	concept	0.50
disease	causes	disease	0.50

Incoming (18)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:PRESENILIN-2	data_in	dataset_row	0.00
DEMENTIA	causes	gene	0.60
ALZHEIMER	associated_with	gene	0.60
PRESENILIN	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
AMYLOID	causes	gene	0.60
GENES	causes	gene	0.60
AMYLOID	activates	gene	0.60
ALZHEIMER	causes	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
PRESENILIN	causes	gene	0.60
ALZHEIMER'S DISEASE	causes	gene	0.60
APOPTOSIS	activates	gene	0.60
NOTCH	activates	gene	0.60
PRESENILIN-1	causes	gene	0.60
PSEN2	associated_with	gene	0.60
PSEN1	causes	gene	0.60
presenilin-1	causes	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning presenilin-2 in their description or question text

No additional research found