concept

AMYLOID BETA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AMYLOID BETA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

711Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	AMYLOID BETA
Key Genes/Proteins	ABCA1, Alpha-Synuclein, ALPHA-SYNUCLEIN, AMBRA1, AMPK, AMYLOID
Related Diseases	acetylcholine, ALZHEIMER, Alzheimer Disease, Alzheimer's disease, Alzheimer's Disease

Pathway Diagram

graph TD
    AMYLOID_BETA["AMYLOID BETA"]
    AMYLOID_BETA -->|"contributes to"| Alzheimer_s_Disease["Alzheimer's Disease"]
    AMYLOID_BETA -->|"binds"| Microglia["Microglia"]
    AMYLOID_BETA -->|"activates"| Microglial_Activation["Microglial Activation"]
    AMYLOID_BETA -->|"contributes to"| MAP1LC3B["MAP1LC3B"]
    AMYLOID_BETA -->|"contributes to"| SQSTM1["SQSTM1"]
    AMYLOID_BETA -->|"activates"| astrocytes["astrocytes"]
    AMYLOID_BETA -->|"regulates"| autophagy["autophagy"]
    AMYLOID_BETA -->|"causes"| reactive_astrocytes["reactive astrocytes"]
    AMYLOID_BETA -->|"activates"| Autophagy["Autophagy"]
    MAP1LC3B -->|"inhibits"| AMYLOID_BETA
    SQSTM1 -->|"inhibits"| AMYLOID_BETA
    Autophagy -->|"targets"| AMYLOID_BETA
    Intramural_Periarterial_Draina["Intramural Periarterial Drainage"] -->|"involved_in"| AMYLOID_BETA
    Glymphatic_Pathway["Glymphatic Pathway"] -->|"mediates"| AMYLOID_BETA
    Dam["Dam"] -->|"interacts"| AMYLOID_BETA
    SCARA1["SCARA1"] -->|"binds"| AMYLOID_BETA
    AGER["AGER"] -->|"binds"| AMYLOID_BETA
    Lysosomes["Lysosomes"] -->|"involved_in"| AMYLOID_BETA
    CD36["CD36"] -->|"binds"| AMYLOID_BETA
    FPR2["FPR2"] -->|"binds"| AMYLOID_BETA

Outgoing (270)

Target	Relation	Type	Str
Alzheimer's Disease	biomarker_for	disease	0.95
Alzheimer'S Disease	causes	disease	0.95
Alzheimer's Disease	contributes_to	disease	0.95
Neuritic Plaques	promotes	phenotype	0.95
Retinal Degeneration	causes	phenotype	0.95
Alzheimer's Disease	associated_with	disease	0.95
Parkinson's Disease with Dementia	associated_with	disease	0.95
Alzheimer'S Disease	contributes_to	disease	0.95
Microglia	activates	cell_type	0.95
Neuroinflammation	causes	process	0.95
Alzheimer's Disease	drives	disease	0.95
Neuritic Plaques	involved_in	phenotype	0.95
Alzheimer Disease	involved_in	disease	0.95
Parkinson'S Disease With Dementia	involved_in	disease	0.95
ALZHEIMER'S DISEASE	associated_with	disease	0.92
Optic Nerve Sheath	transports	cell_type	0.90
Cognitive Decline	contributes_to	phenotype	0.90
Microglia	interacts_with	cell_type	0.90
Retina	expressed_in	cell_type	0.90
Striatum	associated_with	brain_region	0.90
Central Neuroinflammation	causes	process	0.90
Oxidative Stress	causes	process	0.90
Microglia Activation	activates	process	0.90
Alzheimer's Disease	causes	disease	0.90
Alzheimer'S Disease	biomarker_for	disease	0.90
TRKB	degrades	protein	0.90
Senile Plaques	contributes_to	phenotype	0.90
Alzheimer Disease	causes	disease	0.90
microglia activation	promotes	process	0.90
Amyloid Plaques	mediates	phenotype	0.90
MAP1LC3B	contributes_to	gene	0.90
LC3B	upregulates	gene	0.90
SQSTM1	upregulates	gene	0.90
SQSTM1	contributes_to	gene	0.90
Synaptic Plasticity	inhibits	process	0.88
Synaptic Structure	modulates	phenotype	0.88
neuroinflammation	promotes	process	0.88
Insulin Resistance	promotes	process	0.85
LRP8	antagonizes	protein	0.85
Visual Impairment	causes	phenotype	0.85
Neuron	causes	cell_type	0.85
Tau Pathology	causes	process	0.85
Alzheimer's Disease Progression	associated_with	process	0.85
Lipid Dyshomeostasis	causes	phenotype	0.85
Insulin Resistance	contributes_to	process	0.85
Chronic Neuroinflammation	causes	process	0.85
Neuronal Apoptosis	causes	process	0.85
Lysosomal Dysfunction	associated_with	process	0.85
Apoptosis	causes	process	0.85
Oligodendrocyte Progenitor Cell Senescence	causes	process	0.85

Incoming (441)

Source	Relation	Type	Str
APP	expresses	gene	1.00
Anti-Amyloid Beta Therapies	targets	drug	0.95
Alzheimer'S Disease	associated_with	disease	0.95
Donanemab	targets	drug	0.95
Γ-SECRETASE	cleaves	enzyme	0.95
APP	mediates	protein	0.95
Intramural Periarterial Drainage	involved_in	process	0.90
APP	associated_with	gene	0.90
LL37	binds	protein	0.90
Autophagy	targets	process	0.90
Amyloid-Related Imaging Abnormalities	associated_with	biomarker	0.90
Glymphatic System	transports	pathway	0.90
APP	product_of	protein	0.90
MAP1LC3B	inhibits	protein	0.90
Hdac Inhibitors	associated_with	drug	0.90
SQSTM1	inhibits	protein	0.90
Cerebrospinal Fluid	transports	cell_type	0.90
D-520	targets	drug	0.90
Disease-Associated Microglia	interacts_with	cell_type	0.90
Amyloid-targeting therapy	associated_with	process	0.90
BACE1	causes	gene	0.90
Autophagy	degrades	process	0.90
Lyso-Chr2	promotes	protein	0.90
AQP4	associated_with	gene	0.90
Ocular Glymphatic System	transports	process	0.90
Defective Insulin Signaling	upregulates	process	0.85
Tirzepatide	inhibits	drug	0.85
ACE1	associated_with	enzyme	0.85
Secretases	regulates	enzyme	0.85
Microglia	involved_in	cell_type	0.85
Lysosomes	involved_in	cell_type	0.85
Blood-Brain Barrier	transports	brain_region	0.85
Hdac Inhibitors	inhibits	drug	0.85
Disease-modifying therapy	targets	drug	0.85
APP	regulates	entity	0.85
reactive oxygen species	contributes_to	phenotype	0.80
IDE	degrades	protein	0.80
AUTOPHAGY	clears	process	0.80
PARKIN	interacts_with	gene	0.80
Oxidative Stress	upregulates	process	0.80
Hyperbaric Oxygen Therapy	targets	drug	0.80
APOE	transports	protein	0.80
Microglia	transports	cell_type	0.80
Mitochondrial Dysfunction	upregulates	process	0.80
APOE	interacts_with	gene	0.80
MTOR	enhances	gene	0.80
LRP1	regulates	gene	0.80
alpha synuclein	interacts_with	protein	0.80
astrocytic autophagy	inhibits	phenotype	0.80
Astrocytes	interacts_with	cell_type	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AMYLOID BETA in their description or question text

No additional research found