protein

SIGMA1R

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SIGMA1R: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3Connections

0Hypotheses

0Analyses

3Outgoing

0Incoming

0Experiments

0Debates

Summary

Page for Sigma1R Protein

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🔬 Protein Info

Gene Symbol	SIGMAR1
Full Name	Sigma Non-Opioid Intracellular Receptor 1
Aliases	SIGMAR1 gene
Chromosome	9p13.3
Protein Type	Receptor
Function	The SIGMAR1 gene encodes a transmembrane protein that functions as a ligand-operated chaperone with unique pharmacological properties[@su2016].
Primary Expression	Motor cortex, Spinal cord, Liver, Heart, Brain
Amino Acids	223 aa
UniProt ID	Q9Y6D5
NCBI Gene ID	10285
Ensembl ID	ENSG00000147955
OMIM	614514
GeneCards	SIGMAR1
Human Protein Atlas	SIGMAR1
Interactions	NF-KAPPAB, NOX4, POLY-PR
KG Connections	3 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SIGMA1R — AlphaFold Q9Y6D5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SIGMAR1 Gene

gene · 678 words

→

Pathway Diagram

graph TD
    SIGMA1R["SIGMA1R"]
    neurodegeneration["neurodegeneration"]
    SIGMA1R -->|"implicated_in"| neurodegeneration
    style SIGMA1R fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (3)

Target	Relation	Type	Str
NF-KAPPAB	interacts_with	protein	0.80
NOX4	inhibits	gene	0.80
POLY-PR	interacts_with	protein	0.80

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SIGMA1R in their description or question text

No additional research found