protein

PSD-95

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PSD-95: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

121Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

Page for PSD-95 Protein

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	PSD
Chromosome	17p13.1
Function	Psd 95 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease p...
Pathways	Synaptic Signaling
GeneCards	PSD
Human Protein Atlas	PSD
Layer 2	Intermediate scaffolds (GKAP/SAPAP, Shank proteins)
NMDA receptor] receptors	PSD-95 binds NMDA receptor receptor] GluN2 subunits, anchoring them at the synapse and coupling them to downstream signaling pathways (nNOS, SynGAP, Ras/ERK)
AMPA receptors	PSD-95 indirectly clusters AMPA receptors via stargazin/TARP auxiliary subunits, regulating synaptic AMPA receptor content — the primary determinant of synaptic strength
Receptor density	PSD-95 content sets the maximum receptor capacity at each synapse, directly controlling synaptic efficacy[@elias2006]
LTP	Insertion of additional AMPA receptors into PSD-95 scaffolds strengthens the synapse
LTD	Removal of AMPA receptors from PSD-95 slots weakens the synapse
Structural plasticity	PSD-95 content correlates with dendritic spine size, linking molecular organization to synaptic morphology
Physiological	Supports synaptic signaling and plasticity at normal activation levels
Pathological	During excitotoxicity (excessive glutamate stimulation), the PSD-95/nNOS complex generates toxic levels of NO, leading to peroxynitrite formation, DNA damage, and neuronal death
Associated Diseases	Alzheimer's disease
Known Drugs/Compounds	CN2097, Syn3
Interactions	ABCA1, AMYLOID, APOE, APOE4, AQP1, BDNF
KG Connections	121 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PSD_95["PSD-95"]
    BDNF_signaling(["BDNF signaling"])
    PSD_95 -->|"associated with"| BDNF_signaling
    PSD_95 -->|"regulates"| BDNF_signaling
    SAP97["SAP97"]
    PSD_95 -->|"interacts with"| SAP97
    GluR_A["GluR-A"]
    PSD_95 -->|"regulates"| GluR_A
    CN2097["CN2097"]
    CN2097 -->|"interacts with"| PSD_95
    Syn3["Syn3"]
    Syn3 -->|"interacts with"| PSD_95
    style PSD_95 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (68)

Target	Relation	Type	Str
BDNF signaling	regulates	pathway	0.90
BDNF signaling	associated_with	pathway	0.90
Synaptic Plasticity	involved_in	process	0.85
glutamate signaling	participates_in	pathway	0.85
neurons	expressed_in	cell_type	0.85
SAP97	interacts_with	protein	0.80
Synaptic Dysfunction	protects_against	process	0.80
synaptic plasticity	participates_in	pathway	0.75
GluR-A	regulates	protein	0.70
synaptic_plasticity	enhances	pathway	0.70
oxidative stress response	participates_in	pathway	0.65
neurotrophin signaling	participates_in	pathway	0.65
SNAP-25	biomarker_for	gene	0.65
astrocytes	expressed_in	cell_type	0.65
excitatory synapses	involved_in	cellular_location	0.60
SHANK	interacts_with	protein	0.60
NEUREXIN	interacts_with	protein	0.60
NEUROLIGIN	interacts_with	protein	0.60
epigenetic regulation	participates_in	pathway	0.55
microglia	expressed_in	cell_type	0.55
PSEN1	expressed_in	gene	0.55
Alzheimer's disease	expressed_in	disease	0.55
stem cells	expressed_in	cell_type	0.55
TNF	activates	gene	0.55
Alzheimer's disease	associated_with	disease	0.55
TOMM20	activates	gene	0.55
complement cascade	participates_in	pathway	0.55
PSEN1	biomarker_for	gene	0.55
TFAM	biomarker_for	gene	0.55
Alzheimer's disease	biomarker_for	disease	0.55
SAP97	activates	gene	0.55
tauopathy	biomarker_for	disease	0.55
SNAP-25	protects_against	gene	0.55
neurodegeneration	protects_against	disease	0.55
unfolded protein response	participates_in	pathway	0.55
REST	inhibits	gene	0.55
SYN1	inhibits	gene	0.55
SYP	inhibits	gene	0.55
SYNAPSE	interacts_with	concept	0.50
Hippocampus	activates	entity	0.50
Neuroinflammatory	activates	pathway	0.50
Astrocytes	activates	cell_type	0.50
EXERCISE	activates	concept	0.50
APP/PS1	activates	concept	0.50
Proteins	activates	protein	0.50
HMGCR	activates	gene	0.50
Cholesterol	activates	pathway	0.50
ACAT1	activates	concept	0.50
Cortex	activates	brain_region	0.50
FRONTAL	activates	concept	0.50

Incoming (53)

Source	Relation	Type	Str
Syn3	interacts_with	drug	0.90
CN2097	interacts_with	drug	0.90
Methionine Restriction	upregulates	process	0.85
BDNF	upregulates	protein	0.85
NMDA	associated_with	gene	0.75
APOE4	activates	gene	0.65
APP	biomarker_for	gene	0.65
NMDA	interacts_with	gene	0.65
PTK2B	interacts_with	gene	0.60
PTK2B	modulates	gene	0.60
NMDAR	activates	gene	0.55
AQP1	activates	gene	0.55
DLG4	inhibits	gene	0.55
GRIA1	inhibits	gene	0.55
NRSF	inhibits	gene	0.55
APP	expressed_in	gene	0.55
NGF	activates	gene	0.55
MCU	biomarker_for	gene	0.55
BDNF	protects_against	gene	0.55
CREB1	protects_against	gene	0.55
NLGN1	interacts_with	gene	0.55
CD68	activates	gene	0.55
CYP46A1	biomarker_for	gene	0.55
PS1	biomarker_for	gene	0.55
G3BP1	expressed_in	gene	0.55
CD38	associated_with	gene	0.55
NMDAR	associated_with	gene	0.55
GFAP	biomarker_for	gene	0.55
MAP1B	activates	gene	0.55
ANXA1	associated_with	gene	0.55
ABCA1	activates	gene	0.50
CYP46A1	activates	gene	0.50
LDLR	activates	gene	0.50
NMDA	inhibits	protein	0.50
NMDA	activates	protein	0.50
APOE	activates	gene	0.50
GFAP	activates	gene	0.50
AUTISM	interacts_with	disease	0.50
DLG4	interacts_with	gene	0.50
AUTISM	associated_with	disease	0.50
DLG4	associated_with	gene	0.50
SYNAPTOPHYSIN	activates	gene	0.50
MAP2	activates	gene	0.50
NMDA	expressed_in	protein	0.50
SYNGAP	interacts_with	protein	0.50
ERK1	activates	gene	0.50
TGM2	expressed_in	gene	0.50
SYN3	interacts_with	gene	0.50
DEPRESSION	activates	disease	0.50
BDNF	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What neural circuits encode and maintain multi-generational migratory route memo

spatial memory | 2026-04-08 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The paper describes memory-based migration routes maintained across generations

closed · Rounds: 4 · Score: 0.95 · 2026-04-09

Related Research

Hypotheses and analyses mentioning PSD-95 in their description or question text

No additional research found