Contents

NMDA Receptor Subunit NR1 (GRIN1)

🔬 Protein Info

Gene Symbol	NMDAR1
Function	The NMDA receptor subunit NR1 (GRIN1 gene product) is the obligatory subunit of all functional NMDA receptors.
Subcellular Localization	Plasma membrane, postsynaptic density
Molecular Weight	105 kDa
UniProt ID	P35439
GeneCards	NMDAR1
Human Protein Atlas	NMDAR1
Memantine	Low-affinity uncompetitive NMDA antagonist; approved for moderate-to-severe AD; blocks excessive activation while preserving physiological signaling
Amantadine	NMDA antagonist with additional mechanisms; used for PD dyskinesia
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

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