protein 1,147 words KG: NEAT1
Contents

NEAT1 (Nuclear Enriched Abundant Transcript 1)

🔬 Protein Info
Gene SymbolNEAT1
Chromosome11q13.1
Functionis a nuclear long non-coding RNA that serves as the essential structural scaffold for paraspeckles — nuclear bodies involved in gene expression regulation.
Primary ExpressionUbiquitous, highest in brain, heart, muscle
Subcellular LocalizationNucleus (paraspeckles)
Molecular Weight23 kDa
PathwaysBlood-Brain Barrier, Endocytosis, Epigenetic, Microrna, Oxidative Stress
GeneCardsNEAT1
Human Protein AtlasNEAT1
Associated DiseasesALS, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Atherosclerosis, cancer, Colorectal Cancer
InteractionsAGING, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID
SciDEX HypothesesA-Tract Bulge Conserved Motifs Enable Selective Ta
KG Connections294 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (13)

Cryptic Exon Silencing Restoration
Score: 0.53
Circadian Clock-Autophagy Synchronization
Score: 0.76
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
Phase-Separated Organelle Targeting
Score: 0.73
Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72

Related Analyses (6)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

See Also (11)

Amyotrophic Lateral Sclerosis
redirect · KG edge: activates
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
ATF2 — Activating Transcription Factor 2
gene · KG edge: activates

Knowledge Graph (12 edges)

NEAT1 regulates TDP-43
PYCARD associated_with NEAT1
HMOX1 regulates NEAT1
CASP1 associated_with NEAT1
NAMPT associated_with NEAT1
TNF associated_with NEAT1
NOD2 associated_with NEAT1
NEAT1 associated_with CTSD
NEAT1 associated_with TNFRSF21
BECLIN1 associated_with NEAT1

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