gene

MYOT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MYOT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

150Connections

0Hypotheses

0Analyses

50Outgoing

26Incoming

0Experiments

0Debates

Summary

Comprehensive analysis of MYOT gene encoding myotilin protein in myofibrillar myopathy, inclusion body myositis, and related neuromuscular disorders with implications for neurodegenerative disease research

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🧬 Gene Info

Gene Symbol	MYOT
Chromosome	19q13.33
Function	is a gene encoding a Z-disc protein critical for sarcomere organization and maintenance.
Molecular Weight	57 kDa
Amino Acids	493 aa
Exons	13
Pathways	ubiquitin-proteasome
Ensembl ID	ENSG00000136244
GeneCards	MYOT
Human Protein Atlas	MYOT
Associated Diseases	myofibrillar myopathy
Interactions	AUTOPHAGY, BRCA1, DES, DNAJB6, FLNC, GENES
KG Connections	150 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MYOT Gene

gene · 2230 words

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Pathway Diagram

graph TD
    MYOT["MYOT"]
    Myofibrillar_Myopathy{"Myofibrillar Myopathy"}
    MYOT -->|"causes"| Myofibrillar_Myopathy
    myofibrillar_myopathy{"myofibrillar myopathy"}
    MYOT -->|"causes"| myofibrillar_myopathy
    NBR1["NBR1"]
    MYOT -->|"degrades"| NBR1
    P62["P62"]
    MYOT -->|"degrades"| P62
    SQSTM1["SQSTM1"]
    MYOT -->|"degrades"| SQSTM1
    BRCA1["BRCA1"]
    BRCA1 -->|"degrades"| MYOT
    DES["DES"]
    DES -->|"degrades"| MYOT
    DNAJB6["DNAJB6"]
    DNAJB6 -->|"degrades"| MYOT
    FLNC["FLNC"]
    FLNC -->|"degrades"| MYOT
    style MYOT fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (124)

Target	Relation	Type	Str
Myofibrillar Myopathy	causes	disease	0.95
myofibrillar myopathy	causes	disease	0.70
Autophagy	associated_with	pathway	0.60
Proteasome	associated_with	pathway	0.60
SQSTM1	associated_with	gene	0.60
TTN	associated_with	gene	0.60
GENES	associated_with	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
FLNC	associated_with	gene	0.60
DNAJB6	associated_with	gene	0.60
AND	associated_with	gene	0.60
NBR1	degrades	entity	0.60
P62	degrades	entity	0.60
SQSTM1	degrades	entity	0.60
P62	associated_with	gene	0.60
DES	associated_with	gene	0.60
BRCA1	associated_with	gene	0.60
Ca1	expressed_in	brain_region	0.55
Proteins	associated_with	protein	0.50
NBR1	activates	gene	0.50
P62	activates	protein	0.50
P62/SQSTM1	associated_with	protein	0.50
NBR1	associated_with	gene	0.50
ATG	co_discussed	gene	0.40
BIM	co_discussed	protein	0.40
FRONTOTEMPORAL DEMENTIA	co_discussed	disease	0.40
ACTIN	co_discussed	protein	0.40
MAP1LC3	co_discussed	gene	0.40
RAPAMYCIN	co_discussed	drug	0.40
TARDBP/TDP-43	co_discussed	protein	0.40
TAR	co_discussed	protein	0.40
DNA	co_discussed	protein	0.40
UNFOLDED PROTEIN RESPONSE	co_discussed	pathway	0.40
UBIQUITIN-PROTEASOME	co_discussed	pathway	0.40
AMPK	co_discussed	protein	0.40
APOPTOSIS	co_discussed	process	0.40
FTD	co_discussed	disease	0.40
CATALASE	co_discussed	protein	0.40
CELL CYCLE	co_discussed	pathway	0.40
COPD	co_discussed	disease	0.40
EIF2Α	co_discussed	protein	0.40
LC3B	co_discussed	protein	0.40
NLR	co_discussed	gene	0.40
PARKINSON	co_discussed	gene	0.40
PRESENILIN	co_discussed	protein	0.40
RAS	co_discussed	protein	0.40
REACTIVE OXYGEN SPECIES	co_discussed	process	0.40
INTERFERON	co_discussed	protein	0.40
ALS	co_discussed	disease	0.40
CHMP2B	co_discussed	gene	0.40

Incoming (26)

Source	Relation	Type	Str
DES	associated_with	gene	0.60
P62	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
FLNC	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
BRCA1	associated_with	gene	0.60
DNAJB6	associated_with	gene	0.60
GENES	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
BRCA1	degrades	entity	0.60
DES	degrades	entity	0.60
DNAJB6	degrades	entity	0.60
FLNC	degrades	entity	0.60
BRCA1	activates	protein	0.50
DES	activates	gene	0.50
DNAJB6	activates	gene	0.50
FLNC	activates	gene	0.50
AUTOPHAGY	activates	gene	0.50
GENES	activates	gene	0.50
P62/SQSTM1	activates	protein	0.50
ABCD3	co_discussed	gene	0.40
ALZHEIMER DISEASE	co_discussed	gene	0.40
RELA	co_discussed	gene	0.40
NEURODEGENERATIVE DISEASES	co_discussed	disease	0.40
AUTOPHAGY	co_discussed	process	0.40
NEURON	co_discussed	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MYOT in their description or question text

No additional research found