protein

P62/SQSTM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P62/SQSTM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

51Connections

0Hypotheses

1Analyses

24Outgoing

27Incoming

0Experiments

1Debates

Summary

Page for p62/SQSTM1 Protein

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🔬 Protein Info

Gene Symbol	P62/SQSTM1
Chromosome	5q35.
Molecular Weight	62 kDa
Amino Acids	440 aa
Pathways	NF-κB, NF-κB signaling
P392L	the most common mutation, originally identified in Paget disease of bone and subsequently linked to ALS
L341V, P348L	affect the LIR domain, disrupting LC3 binding
K238E, D337E	impair NF-κB signaling or autophagy flux
Associated Diseases	Alzheimer'S Disease, ALS
Interactions	CGAS, MYOT, NBR1, NEMO, OPTN, P62
KG Connections	40 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

p62/SQSTM1 (Sequestosome-1)

entity · 1414 words

→

Pathway Diagram

graph TD
    P62_SQSTM1["P62/SQSTM1"]
    NBR1["NBR1"]
    P62_SQSTM1 -->|"activates"| NBR1
    SQSTM1["SQSTM1"]
    P62_SQSTM1 -->|"co discussed"| SQSTM1
    STING["STING"]
    P62_SQSTM1 -->|"co discussed"| STING
    UBIQUITIN["UBIQUITIN"]
    P62_SQSTM1 -->|"co discussed"| UBIQUITIN
    WAS["WAS"]
    P62_SQSTM1 -->|"activates"| WAS
    MYOT["MYOT"]
    P62_SQSTM1 -->|"activates"| MYOT
    P62["P62"]
    P62_SQSTM1 -->|"activates"| P62
    Cgas_Sting["Cgas-Sting"]
    P62_SQSTM1 -->|"activates"| Cgas_Sting
    NF__B["NF-kappaB"]
    P62_SQSTM1 -->|"activates"| NF__B
    Toll_Like_Receptor["Toll-Like Receptor"]
    P62_SQSTM1 -->|"activates"| Toll_Like_Receptor
    SYNUCLEIN["SYNUCLEIN"]
    P62_SQSTM1 -->|"activates"| SYNUCLEIN
    NEMO["NEMO"]
    P62_SQSTM1 -->|"interacts with"| NEMO
    HSP27["HSP27"]
    P62_SQSTM1 -->|"regulates"| HSP27
    SELECTIVE_AUTOPHAGY["SELECTIVE AUTOPHAGY"]
    P62_SQSTM1 -->|"regulates"| SELECTIVE_AUTOPHAGY
    BRCA1["BRCA1"]
    P62_SQSTM1 -->|"associated with"| BRCA1
    Proteins["Proteins"]
    P62_SQSTM1 -->|"associated with"| Proteins
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"]
    P62_SQSTM1 -->|"activates"| NEURODEGENERATIVE_DISORDERS
    disease["disease"]
    P62_SQSTM1 -->|"activates"| disease
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"co discussed"| P62_SQSTM1
    BRCA1["BRCA1"]
    BRCA1 -->|"co discussed"| P62_SQSTM1
    DES["DES"]
    DES -->|"co discussed"| P62_SQSTM1
    DNAJB6["DNAJB6"]
    DNAJB6 -->|"co discussed"| P62_SQSTM1
    FLNC["FLNC"]
    FLNC -->|"co discussed"| P62_SQSTM1
    Autophagy["Autophagy"]
    Autophagy -->|"activates"| P62_SQSTM1
    CGAS["CGAS"]
    CGAS -->|"activates"| P62_SQSTM1
    SQSTM1["SQSTM1"]
    SQSTM1 -->|"activates"| P62_SQSTM1
    TBK1["TBK1"]
    TBK1 -->|"activates"| P62_SQSTM1
    STING["STING"]
    STING -->|"activates"| P62_SQSTM1
    microglia["microglia"]
    microglia -->|"activates"| P62_SQSTM1
    TLR4["TLR4"]
    TLR4 -->|"activates"| P62_SQSTM1

Outgoing (24)

Target	Relation	Type	Str
h-1111ac0598	targeted_by	hypothesis	1.00
LC3	binds	protein	0.90
Alzheimer'S Disease	biomarker_for	disease	0.85
ALS	biomarker_for	disease	0.85
LC3	interacts_with	protein	0.70
autophagy	regulates	process	0.70
NEURODEGENERATIVE DISORDERS	activates	concept	0.50
disease	activates	disease	0.50
NF-κB	activates	concept	0.50
NEMO	interacts_with	protein	0.50
HSP27	regulates	protein	0.50
SELECTIVE AUTOPHAGY	regulates	concept	0.50
BRCA1	associated_with	protein	0.50
Proteins	associated_with	protein	0.50
NBR1	activates	gene	0.50
SQSTM1	co_discussed	gene	0.50
STING	co_discussed	gene	0.50
UBIQUITIN	co_discussed	protein	0.50
WAS	activates	protein	0.50
MYOT	activates	gene	0.50
P62	activates	protein	0.50
Cgas-Sting	activates	pathway	0.50
Toll-Like Receptor	activates	pathway	0.50
SYNUCLEIN	activates	concept	0.50

Incoming (27)

Source	Relation	Type	Str
h-1111ac0598	targets	hypothesis	1.00
NF-kB	regulates	pathway	0.90
NEMO	co_localizes	protein	0.80
LC3	interacts_with	protein	0.70
BRCA1	co_discussed	protein	0.50
DES	co_discussed	gene	0.50
DNAJB6	co_discussed	gene	0.50
FLNC	co_discussed	gene	0.50
OPTN	interacts_with	gene	0.50
SQSTM1	interacts_with	gene	0.50
Autophagy	regulates	process	0.50
AUTOPHAGY	co_discussed	gene	0.50
SQSTM1	associated_with	gene	0.50
DNAJB6	associated_with	gene	0.50
FLNC	associated_with	gene	0.50
MYOT	associated_with	gene	0.50
NBR1	associated_with	gene	0.50
Autophagy	interacts_with	process	0.50
BAG3	interacts_with	gene	0.50
SQSTM1	regulates	gene	0.50
SQSTM1	activates	gene	0.50
TBK1	activates	gene	0.50
STING	activates	gene	0.50
microglia	activates	cell_type	0.50
TLR4	activates	gene	0.50
CGAS	activates	protein	0.50
Autophagy	activates	process	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Quantitative proteomics of the aging synapse: protein turnover and aggregation i

proteomics | 2026-04-16 | 7 hypotheses Top: 0.533

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

How does synaptic protein turnover change with age and neurodegeneration, and wh

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning P62/SQSTM1 in their description or question text

No additional research found