protein

WRN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WRN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

26Connections

0Hypotheses

0Analyses

13Outgoing

13Incoming

0Experiments

0Debates

Summary

Page for WRN Protein - Werner Syndrome RecQ Like Helicase

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🔬 Protein Info

Gene Symbol	WRN
Full Name	Werner Syndrome RecQ Like Helicase
Aliases	Page for WRN Protein
Protein Type	Enzyme
Function	WRN is a multifunctional DNA metabolic enzyme:
Molecular Weight	164 kDa
Ensembl ID	ENSG00000113240
GeneCards	WRN
Human Protein Atlas	WRN
Base excision repair (BER)	Processing of oxidative DNA damage
DNA double-strand break repair	Homologous recombination and NHEJ
Telomere maintenance	Prevents telomere dysfunction
Replication fork restart	Resolves stalled replication forks
Associated Diseases	Aging, Ms, Senescence
Interactions	COMPLEMENT, CTC1, LMNA, MDM2, MRE11, MUTYH
KG Connections	26 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

WRN — Werner Syndrome RecQ Like Helicase

gene · 628 words

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WRN Protein - Werner Syndrome RecQ Like Helicase

protein · 718 words

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Pathway Diagram

graph TD
    WRN["WRN"]
    Aging{"Aging"}
    WRN -->|"associated with"| Aging
    Ms{"Ms"}
    WRN -->|"therapeutic target"| Ms
    Senescence{"Senescence"}
    WRN -->|"associated with"| Senescence
    WRN -->|"associated with"| Ms
    DNA["DNA"]
    WRN -->|"associated with"| DNA
    Mitophagy(["Mitophagy"])
    WRN -->|"therapeutic target"| Mitophagy
    MDM2["MDM2"]
    WRN -->|"interacts with"| MDM2
    CTC1["CTC1"]
    WRN -->|"interacts with"| CTC1
    ATM["ATM"]
    WRN -->|"regulates"| ATM
    Complement(["Complement"])
    WRN -->|"interacts with"| Complement
    neurodegeneration["neurodegeneration"]
    WRN -->|"implicated in"| neurodegeneration
    TREX1["TREX1"]
    TREX1 -->|"interacts with"| WRN
    VCP["VCP"]
    VCP -->|"interacts with"| WRN
    NEIL1["NEIL1"]
    NEIL1 -->|"interacts with"| WRN
    COMPLEMENT["COMPLEMENT"]
    COMPLEMENT -->|"interacts with"| WRN
    POLD1["POLD1"]
    POLD1 -->|"interacts with"| WRN
    P53["P53"]
    P53 -->|"interacts with"| WRN
    POT1["POT1"]
    POT1 -->|"interacts with"| WRN
    MRE11["MRE11"]
    MRE11 -->|"interacts with"| WRN
    MUTYH["MUTYH"]
    MUTYH -->|"interacts with"| WRN
    SAMHD1["SAMHD1"]
    SAMHD1 -->|"interacts with"| WRN
    NBS1["NBS1"]
    NBS1 -->|"interacts with"| WRN
    LMNA["LMNA"]
    LMNA -->|"interacts with"| WRN
    style WRN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (13)

Target	Relation	Type	Str
Ms	therapeutic_target	disease	0.65
Aging	associated_with	disease	0.65
Senescence	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Complement	interacts_with	pathway	0.60
CANCER	therapeutic_target	gene	0.60
MDM2	interacts_with	gene	0.60
CTC1	interacts_with	gene	0.60
ATM	regulates	gene	0.60
DNA	associated_with	gene	0.60
Mitophagy	therapeutic_target	pathway	0.60
T Cell	expressed_in	cell_type	0.55

Incoming (13)

Source	Relation	Type	Str
NAD	inhibits	gene	0.60
TREX1	interacts_with	gene	0.60
VCP	interacts_with	gene	0.60
NEIL1	interacts_with	gene	0.60
POLD1	interacts_with	gene	0.60
POT1	interacts_with	gene	0.60
MRE11	interacts_with	gene	0.60
MUTYH	interacts_with	gene	0.60
SAMHD1	interacts_with	gene	0.60
NBS1	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
COMPLEMENT	interacts_with	gene	0.60
P53	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning WRN in their description or question text

No additional research found