protein

BCL-2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BCL-2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1942Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

BCL-2 is a protein involved in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with ALS, Aging, Als. Connected to 1238 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	BCL
Pathways	Leukemia Cell Survival
GeneCards	BCL
Human Protein Atlas	BCL
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, Cancer
Known Drugs/Compounds	APG-2575, dasatinib, kaempferitrin, quercetin, venetoclax, Venetoclax
Interactions	6-OHDA, ABCG2, ABL1, Actin, ADSL, AGING
KG Connections	1903 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    BCL_2["BCL-2"] -->|"promotes"| mitochondrial_outer_membrane_p["mitochondrial outer membrane permeabilization"]
    BCL_2["BCL-2"] -->|"regulates"| Fibrosis["Fibrosis"]
    BCL_2["BCL-2"] -->|"therapeutic target"| Als["Als"]
    BCL_2["BCL-2"] -->|"associated"| Lymphoma["Lymphoma"]
    BCL_2["BCL-2"] -.->|"inhibits"| Cancer["Cancer"]
    BCL_2["BCL-2"] -.->|"inhibits"| Als_1["Als"]
    DAG1["DAG1"] -->|"regulates"| BCL_2["BCL-2"]
    HSPG2["HSPG2"] -->|"regulates"| BCL_2["BCL-2"]
    FOXO1["FOXO1"] -->|"associated"| BCL_2["BCL-2"]
    BAX["BAX"] -->|"associated"| BCL_2["BCL-2"]
    style BCL_2 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1121)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:BCL-2	data_in	dataset_row	0.00
Autophagy	activates	pathway	1.00
Als	therapeutic_target	disease	1.00
Tumor	expressed_in	disease	1.00
Apoptosis	activates	pathway	1.00
Cancer	activates	disease	1.00
Lymphoma	therapeutic_target	disease	1.00
Neuroinflammation	activates	disease	1.00
Tumor	inhibits	disease	1.00
Cancer	therapeutic_target	disease	1.00
BRAIN INJURY	activates	gene	1.00
Apoptosis	associated_with	pathway	1.00
AKT	therapeutic_target	gene	1.00
Lymphoma	regulates	disease	1.00
AKT	activates	gene	1.00
Cardiac	activates	disease	1.00
Apoptosis	therapeutic_target	pathway	1.00
Tumor	therapeutic_target	disease	1.00
Als	regulates	disease	1.00
Inflammation	inhibits	disease	1.00
Tumor	activates	disease	1.00
MTOR	activates	gene	1.00
Apoptosis	regulates	pathway	1.00
AUTOPHAGY	activates	gene	1.00
Apoptosis	expressed_in	pathway	1.00
Leukemia	therapeutic_target	disease	1.00
Inflammation	activates	disease	1.00
Carcinoma	therapeutic_target	disease	1.00
Mtor	activates	pathway	1.00
Als	activates	disease	1.00
Apoptosis	inhibits	pathway	1.00
Pi3K/Akt	activates	pathway	1.00
Pi3K/Akt	therapeutic_target	pathway	1.00
Als	inhibits	disease	1.00
Neurodegeneration	activates	disease	1.00
Drug Resistance	therapeutic_target	pathway	1.00
Oxidative Stress	activates	pathway	1.00
Cancer	inhibits	disease	1.00
Cancer	regulates	disease	1.00
Als	associated_with	disease	1.00
Nf-Κb	therapeutic_target	pathway	1.00
NEUROINFLAMMATION	activates	gene	1.00
NRF2	activates	gene	1.00
P62	activates	gene	1.00
DNA	activates	gene	1.00
MITOCHONDRIA	activates	gene	1.00
Fibrosis	inhibits	disease	0.95
Traumatic Brain Injury	activates	disease	0.95
Alzheimer	activates	disease	0.95
Parkinson	activates	disease	0.95

Incoming (821)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:BCL-2	data_in	dataset_row	0.00
BAX	regulates	gene	1.00
CANCER	inhibits	gene	1.00
BAX	expressed_in	gene	1.00
AMPK	activates	gene	1.00
BAX	activates	gene	1.00
PI3K	therapeutic_target	gene	1.00
TNF	activates	gene	1.00
PI3K	activates	gene	1.00
APOPTOSIS	associated_with	gene	1.00
APOPTOSIS	activates	gene	1.00
TNF-Α	activates	gene	1.00
CANCER	therapeutic_target	gene	1.00
ROS	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
APOPTOSIS	regulates	gene	1.00
APOPTOSIS	therapeutic_target	gene	1.00
CANCER	activates	gene	1.00
BAX	inhibits	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
GENES	activates	gene	1.00
APOPTOSIS	inhibits	gene	1.00
INFLAMMATION	inhibits	gene	1.00
NEURODEGENERATION	activates	gene	1.00
STAT3	activates	gene	1.00
APOPTOSIS	expressed_in	gene	1.00
CANCER	regulates	gene	1.00
NEURODEGENERATIVE DISEASES	activates	gene	1.00
HO-1	activates	gene	1.00
GENES	inhibits	gene	1.00
CYTOKINES	inhibits	gene	1.00
Venetoclax	inhibits	drug	0.95
venetoclax	inhibits	drug	0.95
T3	upregulates	drug	0.95
Venetoclax	targets	drug	0.90
TP53	binds_to	protein	0.90
BCL2	activates	gene	0.90
GENES	therapeutic_target	gene	0.90
PARKINSON'S DISEASE	activates	gene	0.90
GENES	expressed_in	gene	0.90
NF-ΚB	therapeutic_target	gene	0.90
PI3K	inhibits	gene	0.90
PI3K	regulates	gene	0.90
P53	inhibits	gene	0.90
P53	expressed_in	gene	0.90
ASTROCYTES	activates	gene	0.90
PI3K	associated_with	gene	0.90
ROS	regulates	gene	0.90
TNF	inhibits	gene	0.90
JAK2	upregulates	protein	0.88

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BCL-2 in their description or question text

No additional research found