gene

CTC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CTC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

18Connections

0Hypotheses

0Analyses

4Outgoing

14Incoming

0Experiments

0Debates

Summary

CTC1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, expressed in, implicated in. Associated with Ms, Senescence. Connected to 19 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CTC1
Full Name	Conserved Telomere Maintenance Component 1
Chromosome	16p13.3
Function	encodes a essential protein component of the CST complex (CTC1-STN1-TEN1), which plays critical roles in telomere replication, telomere length maintenance, and genome stability.
Primary Expression	Ubiquitous; highest in testis, bone marrow, thymus
Amino Acids	228 aa
UniProt ID	Q2NKJ8
NCBI Gene ID	80224
Ensembl ID	ENSG00000107854
OMIM	613129
GeneCards	CTC1
Human Protein Atlas	CTC1
Associated Diseases	neurodegeneration
Interactions	ATM, MRE11, MUTYH, NBS1, NEIL1, P53
KG Connections	18 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CTC1 — AlphaFold Q2NKJ8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CTC1 Gene

gene · 685 words

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Pathway Diagram

graph TD
    CTC1["CTC1"]
    Senescence{"Senescence"}
    CTC1 -->|"interacts with"| Senescence
    Ms{"Ms"}
    CTC1 -->|"interacts with"| Ms
    ATM["ATM"]
    CTC1 -->|"interacts with"| ATM
    Complement(["Complement"])
    CTC1 -->|"expressed in"| Complement
    neurodegeneration["neurodegeneration"]
    CTC1 -->|"implicated in"| neurodegeneration
    TREX1["TREX1"]
    TREX1 -->|"interacts with"| CTC1
    VCP["VCP"]
    VCP -->|"interacts with"| CTC1
    NEIL1["NEIL1"]
    NEIL1 -->|"interacts with"| CTC1
    COMPLEMENT["COMPLEMENT"]
    COMPLEMENT -->|"expressed in"| CTC1
    POLD1["POLD1"]
    POLD1 -->|"expressed in"| CTC1
    P53["P53"]
    P53 -->|"interacts with"| CTC1
    POT1["POT1"]
    POT1 -->|"interacts with"| CTC1
    MRE11["MRE11"]
    MRE11 -->|"interacts with"| CTC1
    MUTYH["MUTYH"]
    MUTYH -->|"interacts with"| CTC1
    SAMHD1["SAMHD1"]
    SAMHD1 -->|"expressed in"| CTC1
    NBS1["NBS1"]
    NBS1 -->|"interacts with"| CTC1
    LMNA["LMNA"]
    LMNA -->|"expressed in"| CTC1
    style CTC1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (4)

Target	Relation	Type	Str
Senescence	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
ATM	interacts_with	gene	0.60
Complement	expressed_in	pathway	0.60

Incoming (14)

Source	Relation	Type	Str
TREX1	interacts_with	gene	0.60
VCP	interacts_with	gene	0.60
NEIL1	interacts_with	gene	0.60
POLD1	expressed_in	gene	0.60
POT1	interacts_with	gene	0.60
MRE11	interacts_with	gene	0.60
MUTYH	interacts_with	gene	0.60
SAMHD1	expressed_in	gene	0.60
NBS1	interacts_with	gene	0.60
LMNA	expressed_in	gene	0.60
WRN	interacts_with	gene	0.60
MDM2	expressed_in	gene	0.60
COMPLEMENT	expressed_in	gene	0.60
P53	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CTC1 in their description or question text

No additional research found