| Gene Symbol | MRE11 |
| Full Name | MRE11 Homolog, Double Strand Break Repair Nuclease |
| Chromosome | 11q21 |
| Function | MRE11 is a key player in the recognition and processing of DNA double-strand breaks (DSBs), the most cytotoxic form of DNA damage. |
| Primary Expression | neurons and glia throughout the CNS - High expression in proliferating neural progenitor cells - Essential for genomic stability in neural development |
| Molecular Weight | 81 kDa |
| Pathways | Immune Response, autophagy pathway |
| UniProt ID | P43146 |
| Ensembl ID | ENSG00000020922 |
| GeneCards | MRE11 |
| Human Protein Atlas | MRE11 |
| Endonuclease Activity | Cuts DNA internally at damage sites |
| Exonuclease Activity | Removes nucleotides from DNA ends |
| Hairpin Opening | Resolves hairpin and loop structures |
| End Resection | Processes DNA ends for homologous recombination |
| Associated Diseases | Als, Ataxia, Cancer, Colorectal Cancer, Gastric Cancer, Infection |
| Interactions | AND, APOPTOSIS, ATM, BAX, Bcl-2, BCL-2 |
| KG Connections | 80 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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