concept

ENDOSOME

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ENDOSOME: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

494Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ENDOSOME is a concept in neurodegeneration research. Key relationships include: regulates, activates, associated with. Associated with ALS, Als, Alzheimer. Connected to 134 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ENDOSOME
Key Genes/Proteins	Actin, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA, AMYOTROPHIC LATERAL SCLEROSIS
Related Diseases	Als, ALS, Alzheimer, Alzheimer'S Disease, Amyotrophic Lateral Sclerosis
Related Pathways	Amyloid

Pathway Diagram

graph TD
    ENDOSOME["ENDOSOME"]
    ENDOSOME -->|"regulates"| ALS["ALS"]
    ENDOSOME -->|"activates"| Alzheimer["Alzheimer"]
    ENDOSOME -->|"activates"| Tauopathy["Tauopathy"]
    ENDOSOME -->|"regulates"| MITOCHONDRIA["MITOCHONDRIA"]
    ENDOSOME -->|"regulates"| RAB7A["RAB7A"]
    ENDOSOME -->|"regulates"| PINK1["PINK1"]
    ENDOSOME -->|"regulates"| TBK1["TBK1"]
    ENDOSOME -->|"regulates"| ATG9A["ATG9A"]
    ENDOSOME -->|"regulates"| PARKIN["PARKIN"]
    ENDOSOME -->|"regulates"| PTEN["PTEN"]
    ENDOSOME -->|"regulates"| AUTOPHAGY["AUTOPHAGY"]
    ENDOSOME -->|"regulates"| Mitophagy["Mitophagy"]
    VPS16["VPS16"] -->|"participates in"| ENDOSOME
    NF__B["NF-KappaB"] -->|"regulates"| ENDOSOME
    MITOPHAGY["MITOPHAGY"] -->|"regulates"| ENDOSOME
    LYSOSOME["LYSOSOME"] -->|"regulates"| ENDOSOME
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| ENDOSOME
    CHMP6["CHMP6"] -->|"regulates"| ENDOSOME
    ATG9A -->|"regulates"| ENDOSOME
    TBK1 -->|"regulates"| ENDOSOME
    PARKIN -->|"regulates"| ENDOSOME
    AND["AND"] -->|"regulates"| ENDOSOME
    AUTOPHAGY -->|"regulates"| ENDOSOME
    RAB7A -->|"regulates"| ENDOSOME

Outgoing (216)

Target	Relation	Type	Str
neurons	found_in	cell_type	0.90
unfolded protein response	involved_in	pathway	0.80
necroptosis	involved_in	pathway	0.80
Autophagy	regulates	pathway	0.80
AUTOPHAGY	regulates	gene	0.80
Inflammation	activates	disease	0.75
RAB7A	regulates	gene	0.70
cortex	enriched_in	brain_region	0.70
microglia	found_in	cell_type	0.70
TBK1	regulates	gene	0.70
hippocampus	enriched_in	brain_region	0.70
pyroptosis	involved_in	pathway	0.70
autophagy pathway	involved_in	pathway	0.70
BDNF-TrkB signaling	involved_in	pathway	0.70
Hepatocellular Carcinoma	activates	disease	0.65
Cancer	inhibits	disease	0.65
Cardiovascular	activates	disease	0.65
Infection	activates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Carcinoma	activates	disease	0.65
Sepsis	activates	disease	0.65
Als	activates	disease	0.65
PRKN	associated_with	gene	0.65
Alzheimer	activates	disease	0.65
ALS	regulates	disease	0.65
Pyroptosis	activates	disease	0.65
Tumor	activates	disease	0.65
Infection	associated_with	disease	0.65
Tauopathy	activates	disease	0.65
LYSOSOME	associated_with	gene	0.65
RAB7A	associated_with	gene	0.65
Als	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Tauopathy	stabilizes	disease	0.65
Alzheimer	stabilizes	disease	0.65
Ataxia	associated_with	disease	0.65
Atherosclerosis	activates	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Senescence	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Dementia	regulates	disease	0.65
Parkinson	regulates	disease	0.65
TAU	associated_with	gene	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Parkinson	causes	disease	0.65
Amyotrophic Lateral Sclerosis	causes	disease	0.65
Ftd	regulates	disease	0.65
Ms	associated_with	disease	0.65

Incoming (278)

Source	Relation	Type	Str
spinal muscular atrophy	disrupts	disease	0.90
C9ORF72	interacts_with	protein	0.90
VPS16	participates_in	gene	0.80
frontotemporal dementia	disrupts	disease	0.80
Alzheimer's disease	disrupts	disease	0.80
neurodegeneration	disrupts	disease	0.80
BDNF	associated_with	gene	0.80
CHMP4B	transported_by	gene	0.80
CHMP2B	causes	gene	0.70
AKT	activates	gene	0.70
ALS	disrupts	disease	0.70
CHMP2B	transported_by	gene	0.70
BACE1	inhibits	gene	0.70
APP	regulates	gene	0.70
BIN1	regulates	gene	0.70
SORL1	regulates	gene	0.70
BDNF	inhibits	gene	0.70
APP	associated_with	gene	0.70
SQSTM1	co_discussed	gene	0.65
CTSD	co_discussed	gene	0.65
LAMP2	co_discussed	gene	0.65
autophagy	co_discussed	concept	0.65
GRN	regulates	gene	0.60
LRRK2	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
PSEN1	regulates	gene	0.60
MTORC1	regulates	gene	0.60
GFP	expressed_in	gene	0.60
MAP1LC3	expressed_in	gene	0.60
INFLAMMATION	activates	gene	0.60
TMEM106B	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
ALS	regulates	gene	0.60
AND	regulates	gene	0.60
NBN	associated_with	gene	0.60
TPX2	inhibits	gene	0.60
AND	inhibits	gene	0.60
ATM	inhibits	gene	0.60
MDC1	associated_with	gene	0.60
LYSOSOME	expressed_in	gene	0.60
DNA	regulates	gene	0.60
SLC2A1	associated_with	gene	0.60
TFEB	regulates	gene	0.60
ATP13A2	regulates	gene	0.60
DNA	associated_with	gene	0.60
EIF4EBP1	associated_with	gene	0.60
GENES	regulates	gene	0.60
CHMP6	inhibits	gene	0.60
CD2AP	regulates	gene	0.60
BIN1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ENDOSOME in their description or question text

No additional research found