| Gene Symbol | MRE11A |
| Aliases | MRE11APROTEIN |
| Function | Mre11A Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. |
| Subcellular Localization | </strong></td><td>Nucleus (nuclear foci)</td></tr> |
| Molecular Weight | 80 kDa |
| Amino Acids | 708 aa |
| GeneCards | MRE11A |
| Human Protein Atlas | MRE11A |
| Nuclease Active Site | Contains conserved histidine-aspartate (HD) motif for metal-dependent hydrolysis |
| Dimerization Interface | Forms homodimers through C-terminal interactions |
| DNA End Recognition | Bends and unwinds DNA at damage sites |
| NBS1 Interaction Surface | Recruits NBS1 for ATM activation |
| Nuclease domain fold | Similar to the calcineurin-like phosphodiesterases |
| DNA binding groove | Positively charged channel for DNA engagement |
| Dimer arrangement | Antiparrallel dimerization creating dual DNA binding sites |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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