gene

NDUFA4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NDUFA4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections

0Hypotheses

0Analyses

21Outgoing

20Incoming

0Experiments

0Debates

Summary

NDUFA4 Gene

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🧬 Gene Info

Gene Symbol	NDUFA4
Full Name	NADH:Ubiquinone Oxidoreductase Subunit A4
Chromosome	12p13.33
Protein Type	Oxidoreductase
Function	NDUFA4 (NADH:Ubiquinone Oxidoreductase Subunit A4) encodes a core subunit of mitochondrial Complex I (NADH:ubiquinone oxidoreductase), the largest enzyme of the mitochondrial electron transport chain.
Pathways	unfolded protein response
UniProt ID	NDUFA4
Ensembl ID	ENSG00000189090
GeneCards	NDUFA4
Human Protein Atlas	NDUFA4
Associated Diseases	Als, Alzheimer
Known Drugs/Compounds	aducanumab
Interactions	CAPZB, CD81, COX4I1, CYCS, GDI2, NDUFS7
KG Connections	41 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: NDUFA4 — AlphaFold NDUFA4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NDUFA4 Gene

gene · 640 words

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Pathway Diagram

graph TD
    NDUFA4["NDUFA4"]
    Alzheimer{"Alzheimer"}
    NDUFA4 -->|"associated_with"| Alzheimer
    Als{"Als"}
    NDUFA4 -->|"associated_with"| Als
    ALS{"ALS"}
    NDUFA4 -->|"associated_with"| ALS
    AND(["AND"])
    NDUFA4 -->|"regulates"| AND
    MAG(["MAG"])
    NDUFA4 -->|"regulates"| MAG
    ALZHEIMER_S_DISEASE(["ALZHEIMER'S DISEASE"])
    NDUFA4 -->|"associated_with"| ALZHEIMER_S_DISEASE
    MITOCHONDRIA(["MITOCHONDRIA"])
    MITOCHONDRIA -->|"regulates"| NDUFA4
    CD81(["CD81"])
    CD81 -->|"regulates"| NDUFA4
    GDI2(["GDI2"])
    GDI2 -->|"regulates"| NDUFA4
    style NDUFA4 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (21)

Target	Relation	Type	Str
ALS	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
AMYLOID	associated_with	gene	0.60
Aβ	regulates	protein	0.60
Amyloid	associated_with	pathway	0.60
AND	regulates	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
HK1	regulates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
Raf	regulates	protein	0.60
App	associated_with	protein	0.60
MAG	regulates	gene	0.60
PLCB1	regulates	gene	0.60
CD81	regulates	gene	0.60
NDUFS7	regulates	gene	0.60
unfolded protein response	participates_in	pathway	0.55
RNA	activates	gene	0.55
PLCB1	co_expressed_with	gene	0.50
NDUFS7	co_expressed_with	gene	0.50
Proteins	interacts_with	protein	0.50

Incoming (20)

Source	Relation	Type	Str
MITOCHONDRIA	regulates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
CD81	regulates	gene	0.60
GDI2	regulates	gene	0.60
MAG	regulates	gene	0.60
HK1	regulates	gene	0.60
PLCB1	regulates	gene	0.60
NDUFS7	regulates	gene	0.60
CAPZB	regulates	gene	0.60
aducanumab	targets	drug	0.60
COX4I1	activates	gene	0.55
CYCS	activates	gene	0.55
MITOCHONDRIA	interacts_with	cell_type	0.50
PLCB1	interacts_with	gene	0.50
CD81	interacts_with	gene	0.50
GDI2	interacts_with	gene	0.50
CAPZB	interacts_with	protein	0.50
NDUFS7	interacts_with	gene	0.50
HK1	co_expressed_with	gene	0.50
MAG	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NDUFA4 in their description or question text

No additional research found