gene 1,541 words KG: MAG
Contents

MAG Gene

🧬 Gene Info
Gene SymbolMAG
Full NameMyelin-Associated Glycoprotein
Chromosome19q13.12
Protein TypeType I membrane protein, Siglec family
Functionis a critical component of the myelin sheath in the central and peripheral nervous systems.
PathwaysApoptosis, Oxidative Stress
UniProt IDP20916
NCBI Gene ID4099
Ensembl IDENSG00000141670
OMIM159460
GeneCardsMAG
Human Protein AtlasMAG
Extracellular domainContains immunoglobulin-like domains that mediate sialic acid binding
Transmembrane domainSingle pass membrane spanning region
Cytoplasmic domainContains motifs for intracellular signaling and protein interactions
Associated DiseasesAls, Alzheimer
Known Drugs/Compoundsaducanumab
InteractionsAPOPTOSIS, App, ASTROCYTE, AXONAL MITOCHONDRIAL TRANSPORT, CD33, GENES
KG Connections114 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (5)

PARP1 Inhibition Therapy
Score: 0.74
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (14)

ATP P2X3 Receptor Neurons
cell · KG edge: contributes_to
Apoptosis in Neurodegeneration
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
GFAP (Redirect)
redirect · KG edge: inhibits
HDAC6 (Redirect)
redirect · KG edge: inhibits

Knowledge Graph (12 edges)

HDAC6 inhibits MAG
RHOA activates MAG
MAG inhibits MIRO1
CNTN6 upregulates MAG
MOG activates MAG
MBP activates MAG
CD81 regulates MAG
GDI2 regulates MAG
MAG regulates HK1
MAG regulates PLCB1

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