gene

SMAD6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SMAD6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections

0Hypotheses

0Analyses

24Outgoing

19Incoming

0Experiments

0Debates

Summary

Comprehensive page on SMAD6, an inhibitory SMAD that negatively regulates BMP and TGF-beta signaling, with roles in neuroinflammation, synaptic plasticity, and neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	SMAD6
Full Name	SMAD Family Member 6
Chromosome	15q22.21
Protein Type	Inhibitory SMAD, transcription regulator
Function	is a gene located on chromosome 15q22.
Primary Expression	Cortex, Hippocampus, Heart, Lung
Pathways	TGF-β
UniProt ID	O43541
NCBI Gene ID	4092
Ensembl ID	ENSG00000168487
OMIM	607929
GeneCards	SMAD6
Human Protein Atlas	SMAD6
Associated Diseases	Als, Alzheimer, Autoimmune, Cancer, Carcinoma, Diabetes
Interactions	TET2
KG Connections	43 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SMAD6 — AlphaFold O43541 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SMAD6 — SMAD Family Member 6

gene · 2543 words

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Pathway Diagram

graph TD
    SMAD6["SMAD6"]
    Hepatitis{"Hepatitis"}
    SMAD6 -->|"associated with"| Hepatitis
    Glioblastoma{"Glioblastoma"}
    SMAD6 -->|"associated with"| Glioblastoma
    Alzheimer{"Alzheimer"}
    SMAD6 -->|"associated with"| Alzheimer
    Obesity{"Obesity"}
    SMAD6 -->|"associated with"| Obesity
    Diabetes{"Diabetes"}
    SMAD6 -->|"associated with"| Diabetes
    Stroke{"Stroke"}
    SMAD6 -->|"associated with"| Stroke
    Multiple_Sclerosis{"Multiple Sclerosis"}
    SMAD6 -->|"associated with"| Multiple_Sclerosis
    Als{"Als"}
    SMAD6 -->|"associated with"| Als
    Cancer{"Cancer"}
    SMAD6 -->|"associated with"| Cancer
    Carcinoma{"Carcinoma"}
    SMAD6 -->|"associated with"| Carcinoma
    Fibrosis{"Fibrosis"}
    SMAD6 -->|"associated with"| Fibrosis
    Ms{"Ms"}
    SMAD6 -->|"associated with"| Ms
    RORA["RORA"]
    RORA -->|"associated with"| SMAD6
    CANCER["CANCER"]
    CANCER -->|"associated with"| SMAD6
    BMP7["BMP7"]
    BMP7 -->|"associated with"| SMAD6
    CX3CR1["CX3CR1"]
    CX3CR1 -->|"associated with"| SMAD6
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"associated with"| SMAD6
    DIABETES_MELLITUS["DIABETES MELLITUS"]
    DIABETES_MELLITUS -->|"associated with"| SMAD6
    AHR["AHR"]
    AHR -->|"associated with"| SMAD6
    MICRORNAS["MICRORNAS"]
    MICRORNAS -->|"associated with"| SMAD6
    EP300["EP300"]
    EP300 -->|"associated with"| SMAD6
    JUN["JUN"]
    JUN -->|"associated with"| SMAD6
    JAK2["JAK2"]
    JAK2 -->|"associated with"| SMAD6
    CCL20["CCL20"]
    CCL20 -->|"associated with"| SMAD6
    style SMAD6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (24)

Target	Relation	Type	Str
Fibrosis	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Leukemia	associated_with	disease	0.65
Autoimmune	associated_with	disease	0.65
Hepatitis	associated_with	disease	0.65
Glioblastoma	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Obesity	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Als	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Notch	associated_with	pathway	0.60
GATA3	associated_with	gene	0.60
ATF6	associated_with	gene	0.60
MAF	associated_with	gene	0.60
FOXP2	associated_with	gene	0.60
TET2	interacts_with	gene	0.60
TET2	regulates	gene	0.60
TET2	associated_with	gene	0.60
TGF-beta signaling	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60

Incoming (19)

Source	Relation	Type	Str
LRP5	regulates	gene	0.60
LRP5	associated_with	gene	0.60
CD38	associated_with	gene	0.60
FOXP3	associated_with	gene	0.60
PPARG	associated_with	gene	0.60
NOTCH1	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
CYTOKINES	associated_with	gene	0.60
DIABETES MELLITUS	associated_with	gene	0.60
MICRORNAS	associated_with	gene	0.60
RORA	associated_with	gene	0.60
BMP7	associated_with	gene	0.60
CX3CR1	associated_with	gene	0.60
AHR	associated_with	gene	0.60
EP300	associated_with	gene	0.60
JUN	associated_with	gene	0.60
JAK2	associated_with	gene	0.60
CCL20	associated_with	gene	0.60
ALZHEIMER DISEASE	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SMAD6 in their description or question text

No additional research found