gene

IL34

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL34: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

28Connections

0Hypotheses

0Analyses

18Outgoing

10Incoming

0Experiments

0Debates

Summary

IL34 Gene

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🧬 Gene Info

Gene Symbol	IL34
Full Name	Interleukin 34
Chromosome	16q22.1
Function	IL34 is a homodimeric cytokine that binds CSF1R with high affinity, driving microglial development and function.
Primary Expression	neurons and is implicated in neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and multiple sclerosis
UniProt ID	Q86V25
NCBI Gene ID	146433
Ensembl ID	ENSG00000157368
OMIM	612681
GeneCards	IL34
Human Protein Atlas	IL34
Associated Diseases	ALS, Alzheimer's disease, neurodegeneration, Parkinson's disease
Interactions	JAK2, STAT3
KG Connections	28 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: IL34 — AlphaFold Q86V25 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

IL34 Gene

gene · 607 words

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Pathway Diagram

flowchart TD
    N0["IL34"]
    N1["ATXN3"]
    N1 -->|"causes"| N0
    N2["Alzheimer's Disease"]
    N0 -->|"therapeutic target"| N2
    N3["JAK2"]
    N0 -->|"activates"| N3
    N4["STAT3"]
    N0 -->|"activates"| N4
    N5["JAK-STAT signaling"]
    N0 -->|"participates in"| N5
    N6["PILRA"]
    N0 -->|"causes"| N6
    N7["SHARPIN"]
    N0 -->|"causes"| N7
    N8["STX6"]
    N0 -->|"causes"| N8

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    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
    classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef biological_process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef concept fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    class N0 gene
    class N1 gene
    class N2 disease
    class N3 gene
    class N4 gene
    class N5 pathway
    class N6 gene
    class N7 gene
    class N8 gene

Outgoing (18)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:IL34	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Alzheimer'S Disease	therapeutic_target	disease	0.85
Alzheimer's Disease	therapeutic_target	disease	0.85
Schwann cells	expressed_in	cell_type	0.60
Alzheimer's disease	causes	disease	0.60
Parkinson's disease	causes	disease	0.60
ALS	causes	disease	0.60
JAK2	activates	gene	0.60
STAT3	activates	gene	0.60
PILRA	causes	gene	0.60
SHARPIN	causes	gene	0.60
STX6	causes	gene	0.60
TREM2	causes	gene	0.60
neurodegeneration	causes	disease	0.60
JAK-STAT signaling	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
macrophages	expressed_in	cell_type	0.55

Incoming (10)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:IL34	data_in	dataset_row	0.00
genes-il34	describes	wiki_page	1.00
ds-83b31ef18d49	data_in	dataset	1.00
genes-il34	documents	wiki_page	1.00
ATXN3	causes	gene	0.60
BST1	causes	gene	0.60
CR2	causes	gene	0.60
B4GALNT1	causes	gene	0.60
ERBB1	causes	gene	0.60
GPNMB	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IL34 in their description or question text

No additional research found