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mechanism 1,227 words KG: JAK
Contents

JAK-STAT Signaling Pathway in Neurodegeneration

⚙ Mechanism Info
NameJAK
Key Genes/ProteinsABCB1, ABCG2, ABL1, ACHE, AD, AD RISK GENES
Related DiseasesAddiction, aging, Aging
Related PathwaysAdaptive Immunity, Akt
Linked Hypotheses4 hypotheses

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Wikipedia

Related Hypotheses (6)

Liver-Derived Inflammatory Suppressors Downregulate Microgli
Score: 0.63H2: SASP Neutralization via JAK/STAT Inhibition Preserves As
Score: 0.55CNTF-JAK/STAT3 Reprogramming of Trained Microglia to Neuropr
Score: 0.55SASP Transient Suppression vs. Senolytic Elimination: A Ther
Score: 0.52ISG Threshold Model Explains Acute vs Chronic Neurodegenerat
Score: 0.48α4β1 Integrin (VLA-4) and JAK/STAT Pathway
Score: 0.45

Knowledge Graph (12 edges)

IL6 activates JAK
JAK activates STAT3
JAK regulates CHROMATIN
JAK regulates GENE_EXPRESSION
JAK causes Alzheimer's disease
SOCS inhibits JAK
JAK associated_with JAK1
JAK associated_with JAK2
JAK associated_with STAT1
JAK associated_with MAPK

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