gene

GAT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GAT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

24Connections

1Hypotheses

0Analyses

15Outgoing

9Incoming

0Experiments

0Debates

Summary

GAT1 is a gene implicated in neurodegeneration research. Key relationships include: transports, regulates, activates. Associated with ALS, Als, Ms. Connected to 17 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GAT1
Full Name	GABA Transporter 1
Protein Type	Gene
Function	is a sodium-dependent GABA transporter that reuptakes GABA from the synaptic cleft back into presynaptic neurons and surrounding glial cells[@borden1994].
Amino Acids	599 aa
Pathways	oxidative stress response
GeneCards	GAT1
Human Protein Atlas	GAT1
Presynaptic neurons	Particularly GABAergic interneurons
[Astrocytes](/entities/astrocytes)	Throughout gray matter regions
Axon terminals	Especially in cortical and hippocampal circuits
Associated Diseases	Als
Interactions	GAT3, IRF3, STING
KG Connections	24 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GAT1["GAT1"]
    Als{"Als"}
    GAT1 -->|"regulates"| Als
    GAT1 -->|"associated with"| Als
    Ms{"Ms"}
    GAT1 -->|"activates"| Ms
    ALS{"ALS"}
    GAT1 -->|"transports"| ALS
    AQP1["AQP1"]
    GAT1 -->|"regulates"| AQP1
    CFTR["CFTR"]
    GAT1 -->|"regulates"| CFTR
    IRF3["IRF3"]
    GAT1 -->|"activates"| IRF3
    STING["STING"]
    GAT1 -->|"activates"| STING
    GAT1 -->|"transports"| AQP1
    GAT1 -->|"transports"| CFTR
    neurodegeneration["neurodegeneration"]
    GAT1 -->|"implicated in"| neurodegeneration
    CFTR -->|"regulates"| GAT1
    AQP1 -->|"associated with"| GAT1
    CFTR -->|"associated with"| GAT1
    GAT3["GAT3"]
    GAT3 -->|"activates"| GAT1
    CFTR -->|"transports"| GAT1
    AQP1 -->|"transports"| GAT1
    AND["AND"]
    AND -->|"transports"| GAT1
    style GAT1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (15)

Target	Relation	Type	Str
Water Transport	mediates	process	0.85
Ms	activates	disease	0.65
ALS	transports	disease	0.65
Als	transports	disease	0.65
Als	regulates	disease	0.65
Als	associated_with	disease	0.65
AND	transports	gene	0.60
oxidative stress response	participates_in	pathway	0.60
AQP1	regulates	gene	0.60
MCT1	translocates_to	gene	0.60
CFTR	regulates	gene	0.60
IRF3	activates	gene	0.60
STING	activates	gene	0.60
AQP1	transports	gene	0.60
CFTR	transports	gene	0.60

Incoming (9)

Source	Relation	Type	Str
genes-gat1	linked_to	wiki_page	1.00
SLC6A13	associated_with	gene	0.70
AQP1	associated_with	gene	0.60
CFTR	associated_with	gene	0.60
CFTR	regulates	gene	0.60
GAT3	activates	gene	0.60
AQP1	transports	gene	0.60
CFTR	transports	gene	0.60
AND	transports	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Astrocyte-Specific DGAT1 Inhibition to Prevent Lipid Droplet	0.515	lipidomics	Lipid metabolism dysregulation in Alzhei

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GAT1 in their description or question text

No additional research found