Contents

IRF3 Gene

🧬 Gene Info

Gene Symbol	IRF3
Chromosome	19q13.33
Protein Type	Transcription Factor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	most cell types, including: - Neurons and astrocytes in the brain - Microglia - Pe
Molecular Weight	47 kDa
Amino Acids	424 aa
Exons	10
Pathways	Akt, Autophagy, Innate Immunity, Nf-Κb, Pi3K
NCBI Gene ID	7099
GeneCards	IRF3
Human Protein Atlas	IRF3
Associated Diseases	AD, ALI, Als, Atherosclerosis, cancer
Interactions	Actin, AIM2, AKT, AKT1, ALS, ALZHEIMER
KG Connections	459 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

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Knowledge Graph

TBK1 phosphorylates IRF3

IRF3 regulates SMC

MAX inhibits IRF3

CGAS activates IRF3

STING activates IRF3

PARP1 inhibits IRF3

IRF3 regulates MAP3K4

SQSTM1 activates IRF3