gene 779 words KG: IRF1
Contents

IRF1 Gene - Interferon Regulatory Factor 1

🧬 Gene Info
Gene SymbolIRF1
Full NameInterferon Regulatory Factor 1
AliasesPage for IRF1 Gene, Page for IRF1 Protein
Chromosome5q31.1.
Protein TypeTranscription Factor
Functionis a transcription factor encoded by the IRF1 gene located on chromosome 5q31.
Molecular Weight36 kDa
Amino Acids325 aa
PathwaysAutophagy, Cell Cycle, Complement, Immune Response, Immunotherapy
UniProt IDP04855
NCBI Gene ID3659
Ensembl IDENSG00000125347
OMIM147575
GeneCardsIRF1
Human Protein AtlasIRF1
Associated DiseasesAls, Inflammation, Ms, Neuroinflammation
InteractionsACOD1, AND, APOPTOSIS, ATG5, ATXN3, AUTOPHAGY
KG Connections264 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (8)

Cholesterol-CRISPR Convergence Therapy for Neurodegeneration
Score: 0.62
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
Nucleolar Stress Response Normalization
Score: 0.65
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56

Related Analyses (5)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (4)

NPM1-IRF1 protein interaction validation
exploratory · proposed · Score: 0.90
IRF1 transcriptional regulation of Nlrc5 and Ciita promoters
exploratory · proposed · Score: 0.90
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (13)

Apoptosis in Neurodegeneration
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
ADCY9 Gene
gene · KG edge: regulates
ADRA1D Gene
gene · KG edge: regulates
ATG3 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

NPM1 activates IRF1
NLRC5 activates IRF1
CD8 activates IRF1
IRF1 activates CIITA
NDP52 inhibits IRF1
CALCOCO2 inhibits IRF1
IRF1 inhibits ATG5
IRF1 activates CD8
IRF1 activates NPM1
ATG5 inhibits IRF1

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.