| Gene Symbol | IL |
| Full Name | 18 - Interleukin-18 |
| Chromosome | 11q22.2. |
| Function | Interleukin-1 beta (IL-1β) is a potent pro-inflammatory cytokine that plays a central role in the innate immune response and neuroinflammation. |
| GeneCards | IL |
| Human Protein Atlas | IL |
| Pro-inflammatory cytokines | TNF-α, IL-1β |
| Oxidative stress | ROS, mitochondrial dysfunction |
| Elevated levels | IL-18 is significantly elevated in CSF and plasma of AD patients compared to healthy controls |
| Disease correlation | Levels correlate with cognitive decline measured by MMSE and CDR |
| Pathology association | Associated with amyloid-β plaque deposition and tau hyperphosphorylation |
| Conversion prediction | Elevated IL-18 predicts conversion from mild cognitive impairment (MCI) to AD |
| Mechanistic role | Drives neuroinflammation and synaptic dysfunction |
| Therapeutic target | IL-18 neutralization reduces pathology in AD mouse models |
| Associated Diseases | CRC |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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