| Gene Symbol | IL |
| Full Name | 1β Protein |
| Function | Interleukin-1 beta (IL-1β) is a potent pro-inflammatory cytokine that plays a central role in the innate immune response and neuroinflammation. |
| Subcellular Localization | </strong></td><td>Secreted, Cytosol</td></tr> |
| GeneCards | IL |
| Human Protein Atlas | IL |
| Propeptide | 116 aa N-terminal propeptide |
| Mature Form | 153 aa after caspase-1 cleavage |
| Receptor Binding Site | β-trefoil domain mediates interaction with IL-1R1 |
| No Signal Peptide | Secreted via non-conventional pathway (inflammasome-dependent) |
| Caspase-1 Cleavage | Essential for bioactivity (Asp27-Ala28 bond) |
| N-linked Glycosylation | May affect secretion efficiency |
| Acetylation | Found on lysine residues, affects receptor binding |
| Inflammatory Cascade Initiation | Activates NF-κB and MAPK pathways |
| Leukocyte Recruitment | Induces adhesion molecule expression |
| Associated Diseases | CRC |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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