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gene 1,404 words KG: HSP27
Contents

HSPB1 — Heat Shock Protein Family B Member 1

🧬 Gene Info
Gene SymbolHSPB1
Full NameHeat Shock Protein Family B Member 1
AliasesHsp27
Chromosome7q11.23.
Molecular Weight27 kDa
Amino Acids205 aa
PathwaysMAPK Pathway, NF-κB, PI3K
GeneCardsHSPB1
Human Protein AtlasHSPB1
Basal state16-24 subunit oligomers
Stressed stateSmaller oligomers (8-12 mers) with increased chaperone activity
Phosphorylated stateDisassembly to dimers/tetramers
Associated DiseasesAging, Als, Alzheimer, Cardiovascular, disease, Ms
InteractionsActin, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYOTROPHIC LATERAL SCLEROSIS
SciDEX HypothesesHSPB1 Phosphorylation Mimetics to Promote Protecti
KG Connections317 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (10)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68Microbial Inflammasome Priming Prevention
Score: 0.65Vagal Afferent Microbial Signal Modulation
Score: 0.62Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.53Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38

Related Analyses (6)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completedProtein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (14)

Amyotrophic Lateral Sclerosis
redirect · KG edge: regulatesAmyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: inhibitsAstrocytes
entity · KG edge: activatesAutophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: inhibitsComplement System Dysregulation in Neurodegeneration -
gap · KG edge: interacts_with

Knowledge Graph (12 edges)

P62 regulates HSP27
SQSTM1 regulates HSP27
HSP27 regulates SQSTM1
CTSH interacts_with HSP27
C1QB interacts_with HSP27
SOD1 activates HSP27
HSP27 regulates AKT
HSP70 therapeutic_target HSP27
CFTR regulates HSP27
HSP27 regulates UBIQUITIN

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