Contents

HSPB1 Protein

🔬 Protein Info

Gene Symbol	HSPB1
Aliases	Hsp27
Chromosome	7q11.23.
Subcellular Localization	</th><td>Cytoplasm, Nucleus, Mitochondria</td></tr>
Molecular Weight	27 kDa
Amino Acids	205 aa
Pathways	MAPK Pathway, NF-κB, PI3K
GeneCards	HSPB1
Human Protein Atlas	HSPB1
Alpha-crystallin Domain	Central conserved region (~80 aa) critical for dimer formation
N-terminal Region	Variable, involved in substrate binding and oligomerization
C-terminal Region	Important for large oligomer formation (12-32 subunits)
Phosphorylation Sites	Ser15, Ser78, Ser82 (regulate oligomeric state and activity)
Cytoskeletal Stability	Binds to actin filaments, intermediate filaments, and microtubules
Anti-apoptotic	Inhibits caspase activation through direct and indirect pathways [@salminen2013]
Associated Diseases	Aging, Als, Alzheimer, Cardiovascular, disease, Ms
Interactions	Actin, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYOTROPHIC LATERAL SCLEROSIS
SciDEX Hypotheses	HSPB1 Phosphorylation Mimetics to Promote Protecti
KG Connections	321 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

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