| Gene Symbol | GRK2 |
| Full Name | G Protein-Coupled Receptor Kinase 2 |
| Aliases | GRK2/Beta-ARK1 |
| Chromosome | 11q13.4 |
| Protein Family | GRK family (PKA/PKG/PKC-like) |
| Protein Type | Kinase |
| Function | Receptor Activation — Upon ligand binding, GPCRs undergo conformational changes that enable interaction with heterotrimeric G proteins. |
| Molecular Weight | 80 kDa |
| Amino Acids | 729 aa |
| Pathways | autophagy pathway, complement cascade, phagocytosis |
| UniProt ID | [P10147](https://www.uniprot.org/uniprot/P10147) |
| Ensembl ID | ENSG00000188020 |
| OMIM | 109635 |
| GeneCards | GRK2 |
| Human Protein Atlas | GRK2 |
| Associated Diseases | neurodegeneration |
| Known Drugs/Compounds | rapamycin |
| Interactions | ACOX1, Adiponectin, ADIPOQ, AMPK, ATG, AUTOPHAGY |
| KG Connections | 164 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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