gene

FOXG1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FOXG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

61Connections

0Hypotheses

0Analyses

39Outgoing

22Incoming

0Experiments

0Debates

Summary

FOXG1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, expressed in. Associated with Alzheimer, Cancer, Carcinoma. Connected to 44 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	FOXG1
Full Name	FOXG1 — Forkhead Box G1
Aliases	Forkhead Box G1
Chromosome	14q12
Protein Type	Gene
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	some gliomas
Pathways	Autophagy
UniProt ID	Q9J516
NCBI Gene ID	2295
Ensembl ID	ENSG00000176165
GeneCards	FOXG1
Human Protein Atlas	FOXG1
Associated Diseases	presbycusis
Known Drugs/Compounds	aspirin
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AND, ATP, INFLAMMATION, NEURODEGENERATIVE DISEASES
KG Connections	61 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FOXG1 — AlphaFold Q9J516 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

FOXG1 — Forkhead Box G1

gene · 501 words

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Pathway Diagram

graph TD
    FOXG1["FOXG1"]
    autophagy(["autophagy"])
    FOXG1 -->|"regulates"| autophagy
    presbycusis{"presbycusis"}
    FOXG1 -->|"associated with"| presbycusis
    cochlear_hair_cells["cochlear hair cells"]
    FOXG1 -->|"expressed in"| cochlear_hair_cells
    Alzheimer{"Alzheimer"}
    FOXG1 -->|"activates"| Alzheimer
    Neuroinflammation{"Neuroinflammation"}
    FOXG1 -->|"activates"| Neuroinflammation
    Inflammation{"Inflammation"}
    FOXG1 -->|"activates"| Inflammation
    Parkinson{"Parkinson"}
    FOXG1 -->|"regulates"| Parkinson
    Ms{"Ms"}
    FOXG1 -->|"activates"| Ms
    Diabetes{"Diabetes"}
    FOXG1 -->|"expressed in"| Diabetes
    Cancer{"Cancer"}
    FOXG1 -->|"expressed in"| Cancer
    Carcinoma{"Carcinoma"}
    FOXG1 -->|"expressed in"| Carcinoma
    NLRP3["NLRP3"]
    FOXG1 -->|"regulates"| NLRP3
    aspirin["aspirin"]
    aspirin -->|"activates"| FOXG1
    FOXA2["FOXA2"]
    FOXA2 -->|"associated with"| FOXG1
    FOXO6["FOXO6"]
    FOXO6 -->|"associated with"| FOXG1
    FOXK2["FOXK2"]
    FOXK2 -->|"associated with"| FOXG1
    FOXO3["FOXO3"]
    FOXO3 -->|"associated with"| FOXG1
    FOXP3["FOXP3"]
    FOXP3 -->|"associated with"| FOXG1
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"regulates"| FOXG1
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"activates"| FOXG1
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"regulates"| FOXG1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"activates"| FOXG1
    ATP["ATP"]
    ATP -->|"activates"| FOXG1
    style FOXG1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (39)

Target	Relation	Type	Str
presbycusis	associated_with	disease	0.70
cochlear hair cells	expressed_in	cell_type	0.70
autophagy	regulates	process	0.70
Carcinoma	expressed_in	disease	0.65
Inflammation	activates	disease	0.65
Parkinson	regulates	disease	0.65
Ms	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
Diabetes	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
FOXP4	associated_with	gene	0.60
FOXO4	associated_with	gene	0.60
FOXO1	associated_with	gene	0.60
FOXP2	associated_with	gene	0.60
FOXO6	associated_with	gene	0.60
Inflammasome	activates	pathway	0.60
FOXD3	associated_with	gene	0.60
FOXN3	associated_with	gene	0.60
CANCER	expressed_in	gene	0.60
DIABETES MELLITUS	expressed_in	gene	0.60
Epigenetic	expressed_in	pathway	0.60
Hedgehog	expressed_in	pathway	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
ALZHEIMER	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
PARKINSON	regulates	gene	0.60
AND	associated_with	gene	0.60
INFLAMMATION	activates	gene	0.60
AND	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
ASTROCYTES	regulates	gene	0.60
Autophagy	regulates	pathway	0.60
AUTOPHAGY	regulates	gene	0.60
NLRP3	regulates	gene	0.60
SHH	expressed_in	gene	0.60
FOXP1	associated_with	gene	0.60
FOXM1	associated_with	gene	0.60

Incoming (22)

Source	Relation	Type	Str
aspirin	activates	drug	0.70
FOXA2	associated_with	gene	0.60
FOXO6	associated_with	gene	0.60
FOXO3	associated_with	gene	0.60
FOXP3	associated_with	gene	0.60
FOXO1	associated_with	gene	0.60
FOXO4	associated_with	gene	0.60
FOXP1	associated_with	gene	0.60
SHH	expressed_in	gene	0.60
FOXP2	associated_with	gene	0.60
FOXP4	associated_with	gene	0.60
FOXK2	associated_with	gene	0.60
ASTROCYTES	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
ATP	activates	gene	0.60
FOXD3	associated_with	gene	0.60
GENES	expressed_in	gene	0.60
FOXN3	associated_with	gene	0.60
PARKINSON	regulates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FOXG1 in their description or question text

No additional research found