gene

FOXO6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FOXO6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

67Connections

0Hypotheses

0Analyses

45Outgoing

22Incoming

0Experiments

0Debates

Summary

FOXO6 is a gene implicated in neurodegeneration research. Key relationships include: associated with, expressed in, therapeutic target. Associated with Als, Cancer, Carcinoma. Connected to 25 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	FOXO6
Chromosome	1p33
Protein Type	Transcription Factor
Function	Synaptic plasticity: BDNF, ARC, EGR1 immediate early genes
Amino Acids	524 aa
Exons	3
Ensembl ID	ENSG00000204060
GeneCards	FOXO6
Human Protein Atlas	FOXO6
Associated Diseases	Als
Interactions	CANCER
KG Connections	67 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

FOXO6 Gene

gene · 817 words

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Pathway Diagram

graph TD
    FOXO6["FOXO6"]
    Diabetes{"Diabetes"}
    FOXO6 -->|"expressed in"| Diabetes
    Cancer{"Cancer"}
    FOXO6 -->|"expressed in"| Cancer
    Carcinoma{"Carcinoma"}
    FOXO6 -->|"expressed in"| Carcinoma
    Longevity{"Longevity"}
    FOXO6 -->|"therapeutic target"| Longevity
    Als{"Als"}
    FOXO6 -->|"associated with"| Als
    Tumor{"Tumor"}
    FOXO6 -->|"therapeutic target"| Tumor
    FOXK2["FOXK2"]
    FOXO6 -->|"associated with"| FOXK2
    FOXO3["FOXO3"]
    FOXO6 -->|"associated with"| FOXO3
    FOXP3["FOXP3"]
    FOXO6 -->|"associated with"| FOXP3
    FOXG1["FOXG1"]
    FOXO6 -->|"associated with"| FOXG1
    FOXD3["FOXD3"]
    FOXO6 -->|"associated with"| FOXD3
    SHH["SHH"]
    FOXO6 -->|"expressed in"| SHH
    FOXA2["FOXA2"]
    FOXA2 -->|"associated with"| FOXO6
    style FOXO6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (45)

Target	Relation	Type	Str
Als	associated_with	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cardiovascular	contributes_to	disease	0.65
Ms	contributes_to	disease	0.65
Carcinoma	expressed_in	disease	0.65
Diabetes	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Longevity	therapeutic_target	disease	0.65
Longevity	contributes_to	disease	0.65
Cancer	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Cancer	contributes_to	disease	0.65
Aging	contributes_to	disease	0.65
Carcinoma	activates	disease	0.65
CANCER	activates	gene	0.60
GENES	associated_with	gene	0.60
APOPTOSIS	contributes_to	gene	0.60
BIRC5	associated_with	gene	0.60
FOXD3	associated_with	gene	0.60
FOXN3	associated_with	gene	0.60
CANCER	expressed_in	gene	0.60
DIABETES MELLITUS	expressed_in	gene	0.60
Epigenetic	expressed_in	pathway	0.60
Hedgehog	expressed_in	pathway	0.60
Apoptosis	contributes_to	pathway	0.60
CANCER	contributes_to	gene	0.60
FOXK2	associated_with	gene	0.60
FOXO3	associated_with	gene	0.60
FOXP3	associated_with	gene	0.60
FOXG1	associated_with	gene	0.60
SHH	expressed_in	gene	0.60
FOXP1	associated_with	gene	0.60
FOXM1	associated_with	gene	0.60
FOXP4	associated_with	gene	0.60
FOXO4	associated_with	gene	0.60
FOXO1	associated_with	gene	0.60
FOXP2	associated_with	gene	0.60
NR3C1	associated_with	gene	0.60
VIM	associated_with	gene	0.60
CXCL8	associated_with	gene	0.60
AND	associated_with	gene	0.60
T Cell	therapeutic_target	cell_type	0.60
T Cell	expressed_in	cell_type	0.55
DNMT1	associated_with	protein	0.50
Chemoresistance	associated_with	pathway	0.50

Incoming (22)

Source	Relation	Type	Str
FOXA2	associated_with	gene	0.60
NEURODEGENERATIVE DISORDERS	contributes_to	gene	0.60
AGING	contributes_to	gene	0.60
FOXO1	associated_with	gene	0.60
FOXP3	associated_with	gene	0.60
FOXO4	associated_with	gene	0.60
FOXP1	associated_with	gene	0.60
SHH	expressed_in	gene	0.60
FOXO3	associated_with	gene	0.60
FOXP2	associated_with	gene	0.60
FOXP4	associated_with	gene	0.60
FOXG1	associated_with	gene	0.60
VIM	associated_with	gene	0.60
BIRC5	associated_with	gene	0.60
GENES	associated_with	gene	0.60
FOXD3	associated_with	gene	0.60
GENES	expressed_in	gene	0.60
FOXK2	associated_with	gene	0.60
FOXN3	associated_with	gene	0.60
CXCL8	associated_with	gene	0.60
DNMT1	associated_with	gene	0.60
NR3C1	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FOXO6 in their description or question text

No additional research found