concept

DENND1B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DENND1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

0Hypotheses

0Analyses

12Outgoing

2Incoming

0Experiments

0Debates

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💡 Concept Info

Name	DENND1B
Key Genes/Proteins	BACH2, DNMT3A, ERAP2, FUT2, IL10, IL2RA
Related Diseases	Crohn's Disease, Crohn'S Disease
Related Pathways	TGF-beta signaling

Pathway Diagram

graph TD
    DENND1B[DENND1B]
    DENND1B -->|risk_factor_for| Crohn_s_Disease[Crohn's Disease]
    DENND1B -->|implicated in| DNMT3A[DNMT3A]
    DENND1B -->|implicated in| ERAP2[ERAP2]
    DENND1B -->|implicated in| FUT2[FUT2]
    DENND1B -->|implicated in| IL10[IL10]
    DENND1B -->|implicated in| IL2RA[IL2RA]
    DENND1B -->|implicated in| SMAD3[SMAD3]
    DENND1B -->|implicated in| TAGAP[TAGAP]
    DENND1B -->|implicated in| TYK2[TYK2]
    DENND1B -->|participates in| TGF_beta_signaling[TGF-beta signaling]
    BACH2[BACH2] -->|implicated in| DENND1B
    benchmark_ot_ad_answer_key_DEN[benchmark_ot_ad_answer_key:DENND1B] -->|data_in| DENND1B

Outgoing (12)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:DENND1B	data_in	dataset_row	0.00
Crohn'S Disease	associated_with	disease	0.85
Crohn's Disease	risk_factor_for	disease	0.85
TGF-beta signaling	participates_in	pathway	0.60
DNMT3A	implicated_in	gene	0.60
ERAP2	implicated_in	gene	0.60
FUT2	implicated_in	gene	0.60
IL10	implicated_in	gene	0.60
IL2RA	implicated_in	gene	0.60
SMAD3	implicated_in	gene	0.60
TAGAP	implicated_in	gene	0.60
TYK2	implicated_in	gene	0.60

Incoming (2)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:DENND1B	data_in	dataset_row	0.00
BACH2	implicated_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DENND1B in their description or question text

No additional research found