gene

RBPJ

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RBPJ: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

34Connections

0Hypotheses

0Analyses

17Outgoing

17Incoming

0Experiments

0Debates

Summary

RBPJ is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, implicated in. Associated with Als, Cancer, Cardiovascular. Connected to 16 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RBPJ
Full Name	Recombination Signal Binding Protein for Immunoglobulin Kappa J Region
Chromosome	4q25
Protein Type	Transcription Factor
Function	is a critical transcription factor that serves as the primary mediator of Notch signaling.
Primary Expression	cortical layers II-VI, particularly in layer 2/3 pyramidal neurons
Amino Acids	434 aa
Pathways	Notch signaling, Notch, Notch Signaling, NOTCH
UniProt ID	[Q06323](https://www.uniprot.org/uniprot/Q06323)
Ensembl ID	ENSG00000168214
GeneCards	RBPJ
Human Protein Atlas	RBPJ
p53-mediated apoptosis	RBPJ can interact with p53 to modulate apoptotic responses
TFII-I interactions	RBPJ interacts with general transcription factors to regulate housekeeping genes
Chromatin remodeling	RBPJ recruits chromatin modifiers independent of Notch signaling
Associated Diseases	neurodegeneration
Interactions	AKT1, CANCER, CXCL1, NOTCH1, RNA, STAT3
KG Connections	34 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RBPJ["RBPJ"]
    Als{"Als"}
    RBPJ -->|"regulates"| Als
    Cardiovascular{"Cardiovascular"}
    RBPJ -->|"regulates"| Cardiovascular
    Cancer{"Cancer"}
    RBPJ -->|"activates"| Cancer
    CGAS["CGAS"]
    RBPJ -->|"regulates"| CGAS
    DNMT3A["DNMT3A"]
    RBPJ -->|"regulates"| DNMT3A
    LRP6["LRP6"]
    RBPJ -->|"regulates"| LRP6
    NOTCH1["NOTCH1"]
    RBPJ -->|"regulates"| NOTCH1
    Akt(["Akt"])
    RBPJ -->|"activates"| Akt
    Notch(["Notch"])
    RBPJ -->|"regulates"| Notch
    neurodegeneration["neurodegeneration"]
    RBPJ -->|"implicated in"| neurodegeneration
    SNCA["SNCA"]
    SNCA -->|"contributes to"| RBPJ
    TET2["TET2"]
    TET2 -->|"regulates"| RBPJ
    TFAM["TFAM"]
    TFAM -->|"regulates"| RBPJ
    MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
    MITOCHONDRIAL_DNA -->|"regulates"| RBPJ
    AKT1["AKT1"]
    AKT1 -->|"activates"| RBPJ
    CANCER["CANCER"]
    CANCER -->|"activates"| RBPJ
    style RBPJ fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (17)

Target	Relation	Type	Str
Cancer	activates	disease	0.65
Als	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Carcinoma	activates	disease	0.65
Tumor	activates	disease	0.65
Akt	activates	pathway	0.60
Notch	regulates	pathway	0.60
Angiogenesis	activates	pathway	0.60
Notch	activates	pathway	0.60
USP5	activates	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
CGAS	regulates	gene	0.60
RNA	activates	gene	0.60
DNMT3A	regulates	gene	0.60
LRP6	regulates	gene	0.60
NOTCH1	regulates	gene	0.60
Notch signaling	participates_in	pathway	0.60

Incoming (17)

Source	Relation	Type	Str
SNCA	contributes_to	gene	0.80
TET2	regulates	gene	0.60
TFAM	regulates	gene	0.60
CGAS	regulates	gene	0.60
DNMT3A	regulates	gene	0.60
AND	regulates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
DNA	regulates	gene	0.60
IFN	regulates	gene	0.60
AKT1	activates	gene	0.60
NOTCH1	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
VEGF	activates	gene	0.60
STAT3	activates	gene	0.60
CXCL1	activates	gene	0.60
MITOCHONDRIAL DNA	regulates	gene	0.60
CANCER	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RBPJ in their description or question text

No additional research found